文献库，生知库 | 链接生命科学的每一步

Marlene Pils, Alexandra Dybala, Anja Schaffrath, Fabian Rehn, Janine Kutzsche, Lara Blömeke, Markus Tusche, Pelin Özdüzenciler, Tuyen Bujnicki, Victoria Kraemer-Schulien, Hannes Gramespacher, Maximilian H T Schmieschek, Michael T Barbe, Oezguer A Onur, Gereon R Fink, Gültekin Tamgüney, Oliver Bannac

神经

阿尔茨海默症

发表日期：2024

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Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies

所有 D-对映体肽配体对单体 Tau 蛋白的稳定作用作为阿尔茨海默病和其他 Tauo 蛋白病的治疗策略

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms24032161

Tim Altendorf, Ian Gering, Beatrix Santiago-Schübel, Selma Aghabashlou Saisan, Gültekin Tamgüney, Markus Tusche, Dominik Honold, Sarah Schemmert, Wolfgang Hoyer, Jeannine Mohrlüder, Dieter Willbold

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

使用响尾蛇毒中的阳离子肽作为支架设计 D-氨基酸 SARS-CoV-2 主要蛋白酶抑制剂

期刊:Pharmaceuticals

影响因子:

doi:10.3390/ph15050540

Raphael J Eberle, Ian Gering, Markus Tusche, Philipp N Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S Olivier, Marcos S Amaral, Raghuvir K Arni, Dieter Willbold, Mônika A Coronado

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

固态 MAS NMR 光谱揭示淀粉样蛋白 β 寡聚体与人类朊病毒蛋白复合物的结构细节

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2021.100499

Anna S König, Nadine S Rösener, Lothar Gremer, Markus Tusche, Daniel Flender, Elke Reinartz, Wolfgang Hoyer, Philipp Neudecker, Dieter Willbold, Henrike Heise

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

开发用于直接消除淀粉样β蛋白低聚物的D肽RD2的代谢抗性

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-019-41993-6

Anne Elfgen, Michelle Hupert, Kevin Bochinsky, Markus Tusche, Estibaliz González de San Román Martin, Ian Gering, Silvia Sacchi, Loredano Pollegioni, Pitter F Huesgen, Rudolf Hartmann, Beatrix Santiago-Schübel, Janine Kutzsche, Dieter Willbold

代谢

发表日期：2019

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In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease

用于治疗阿尔茨海默病的全 D 对映体肽的体外效力和临床前药代动力学比较

期刊:Journal of Alzheimers Disease

影响因子:3.4

doi:10.3233/JAD-180165

Elena Schartmann, Sarah Schemmert, Nicole Niemietz, Dominik Honold, Tamar Ziehm, Markus Tusche, Anne Elfgen, Ian Gering, Oleksandr Brener, Nadim Joni Shah, Karl-Josef Langen, Janine Kutzsche, Dieter Willbold, Antje Willuweit

阿尔茨海默症

发表日期：2018

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Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease

利用四种最有前景的 D3 衍生物进行大规模口服治疗研究，用于治疗阿尔茨海默病

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules22101693

Janine Kutzsche, Sarah Schemmert, Markus Tusche, Jörg Neddens, Roland Rabl, Dagmar Jürgens, Oleksandr Brener, Antje Willuweit, Birgit Hutter-Paier, Dieter Willbold

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

消除 D-对映体肽 RD2 的 Aβ 寡聚体可改善认知能力，而不会改变斑块病理

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-017-16565-1

Thomas van Groen, Sarah Schemmert, Oleksandr Brener, Lothar Gremer, Tamar Ziehm, Markus Tusche, Luitgard Nagel-Steger, Inga Kadish, Elena Schartmann, Anne Elfgen, Dagmar Jürgens, Antje Willuweit, Janine Kutzsche, Dieter Willbold

信号转导

发表日期：2017

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Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

与 GABARAP 家族成员直接结合对于 HIV-1 Nef 质膜定位至关重要

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-017-06319-4

Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

竞争性镜像噬菌体展示衍生肽调节淀粉样β蛋白的聚集和毒性

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0147470

Stephan Rudolph, Antonia Nicole Klein, Markus Tusche, Christine Schlosser, Anne Elfgen, Oleksandr Brener, Charlotte Teunissen, Lothar Gremer, Susanne Aileen Funke, Janine Kutzsche, Dieter Willbold

微生物学

发表日期：2016

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Elevated Aβ aggregates in feces from Alzheimer's disease patients: a proof-of-concept study

阿尔茨海默病患者粪便中 Aβ 聚集物增多：一项概念验证研究

Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies

所有 D-对映体肽配体对单体 Tau 蛋白的稳定作用作为阿尔茨海默病和其他 Tauo 蛋白病的治疗策略

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

使用响尾蛇毒中的阳离子肽作为支架设计 D-氨基酸 SARS-CoV-2 主要蛋白酶抑制剂

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

固态 MAS NMR 光谱揭示淀粉样蛋白 β 寡聚体与人类朊病毒蛋白复合物的结构细节

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

开发用于直接消除淀粉样β蛋白低聚物的D肽RD2的代谢抗性

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease

用于治疗阿尔茨海默病的全 D 对映体肽的体外效力和临床前药代动力学比较

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease

利用四种最有前景的 D3 衍生物进行大规模口服治疗研究，用于治疗阿尔茨海默病

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

消除 D-对映体肽 RD2 的 Aβ 寡聚体可改善认知能力，而不会改变斑块病理

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

与 GABARAP 家族成员直接结合对于 HIV-1 Nef 质膜定位至关重要

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

竞争性镜像噬菌体展示衍生肽调节淀粉样β蛋白的聚集和毒性