日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress

LRRK2 激酶抑制剂 PF-06447475 保护果蝇免受百草枯引起的运动障碍、寿命缩短和氧化应激

Diana A Quintero-Espinosa, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo

Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson's Disease Dementia (PDD)

鱼藤酮诱导胆碱能样神经元出现类似帕金森病痴呆 (PDD) 的神经病理表型

Daniela Giraldo-Berrio, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio

The GBA1 K198E Variant Is Associated with Suppression of Glucocerebrosidase Activity, Autophagy Impairment, Oxidative Stress, Mitochondrial Damage, and Apoptosis in Skin Fibroblasts

GBA1 K198E 变体与抑制葡萄糖脑苷脂酶活性、自噬受损、氧化应激、线粒体损伤和皮肤成纤维细胞凋亡有关

Laura Patricia Perez-Abshana, Miguel Mendivil-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo

Combination of Tramiprosate, Curcumin, and SP600125 Reduces the Neuropathological Phenotype in Familial Alzheimer Disease PSEN1 I416T Cholinergic-like Neurons

曲米普罗酸盐、姜黄素和 SP600125 的组合可降低家族性阿尔茨海默病 PSEN1 I416T 胆碱能样神经元的神经病理学表型

Nicolas Gomez-Sequeda, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo

Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology

携带 PSEN1 p.Ile416Thr 变体的胆碱能样神经元和脑球体反映阿尔茨海默病神经病理学

Nicolas Gomez-Sequeda, Miguel Mendivil-Perez, Marlene Jimenez-Del-Rio, Francisco Lopera, Carlos Velez-Pardo

Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells

鱼藤酮阻断葡萄糖脑苷脂酶并诱导 HEK-293 细胞中溶酶体和自噬溶酶体的积累,且不依赖于 LRRK2 激酶

Laura Patricia Perez-Abshana, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio

LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis

LRRK2 敲除使 HEK-293 细胞对鱼藤酮诱导的氧化应激、线粒体损伤和细胞凋亡产生抵抗力

Diana Alejandra Quintero-Espinosa, Sabina Sanchez-Hernandez, Carlos Velez-Pardo, Francisco Martin, Marlene Jimenez-Del-Rio

PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent

源自间充质基质细胞和诱导性多能干细胞的 PSEN1 E280A 胆碱能样神经元和大脑球体在神经病理学上是等效的

Miguel Mendivil-Perez, Carlos Velez-Pardo, Francisco Lopera, Kenneth S Kosik, Marlene Jimenez-Del-Rio

High Yield of Functional Dopamine-like Neurons Obtained in NeuroForsk 2.0 Medium to Study Acute and Chronic Rotenone Effects on Oxidative Stress, Autophagy, and Apoptosis

在 NeuroForsk 2.0 培养基中获得高产量的功能性多巴胺样神经元,用于研究急性和慢性鱼藤酮对氧化应激、自噬和细胞凋亡的影响

Diana Alejandra Quintero-Espinosa, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio

TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice

TPEN/TPGS (T2) 联合疗法可显著降低 BALB/c 小鼠费城染色体阳性前淋巴母细胞 B 白血病的发生率

Miguel Mendivil-Perez ,Marlene Jimenez-Del-Rio ,Carlos Velez-Pardo