日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

结合晶体学片段筛选和深度突变扫描,可以发现寨卡病毒NS2B-NS3蛋白酶抑制剂。

Ni, Xiaomin; Richardson, R Blake; Godoy, Andre Schutzer; Ferla, Matteo P; Kikawa, Caroline; Scheen, Jenke; Hannon, William W; Capkin, Eda; Lahav, Noa; Balcomb, Blake H; Marples, Peter G; Fairhead, Michael; Wang, SiYi; Williams, Eleanor P; Tomlinson, Charles W E; Aschenbrenner, Jasmin C; Lithgo, Ryan M; Winokan, Max; Giroud, Charline; Dolci, Isabela; Fernandes, Rafaela Sachetto; Oliva, Glaucius; Chandran, Anu V; Xavier, Mary-Ann; Walsh, Martin A; Thompson, Warren; Bloom, Jesse D; Kenton, Nathaniel T; Lee, Alpha A; von Delft, Annette; Barr, Haim; Kirkegaard, Karla; Koekemoer, Lizbé; Fearon, Daren; Evans, Matthew J; von Delft, Frank

Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals

登革病毒聚合酶晶体学片段筛选揭示了多个结合位点,可用于开发非核苷类抗黄病毒药物

Saini, Manisha; Aschenbrenner, Jasmin C; Ruiz, Francesc Xavier; Chopra, Ashima; Chandran, Anu V; Marples, Peter G; Balcomb, Blake H; Fearon, Daren; von Delft, Frank; Arnold, Eddy

Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain.

晶体学片段筛选揭示了TRIM21 PRY-SPRY结构域中的配体热点

Kim Yeojin, Lučić Aleksandar, Lenz Christopher, Farges Frederic, Schwalm Martin P, Saxena Krishna, Hanke Thomas, Marples Peter G, Aschenbrenner Jasmin C, Fearon Daren, von Delft Frank, Krämer Andreas, Knapp Stefan

Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals

登革病毒聚合酶晶体学片段筛选揭示了多个可用于开发非核苷类抗黄病毒药物的结合位点

Saini, Manisha; Aschenbrenner, Jasmin C; Ruiz, Francesc Xavier; Chopra, Ashima; Chandran, Anu V; Marples, Peter G; Balcomb, Blake H; Fearon, Daren; von Delft, Frank; Arnold, Eddy

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

通过晶体学片段筛选鉴定针对基孔肯雅病毒nsP3宏结构域的新型化学物质

Aschenbrenner, Jasmin C; de Godoy, Andre Schutzer; Fairhead, Michael; Tomlinson, Charles W E; Winokan, Max; Balcomb, Blake H; Capkin, Eda; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Lithgo, Ryan M; Marples, Peter G; Ni, Xiaomin; Thompson, Warren; Wild, Conor; Xavier, Mary-Ann E; Fearon, Daren; von Delft, Frank