日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation

内皮致癌基因KRAS突变驱动脑动静脉畸形中小胶质细胞和巨噬细胞的动态变化

Park, Hyejin; Park, Jung-Eun; Freeman, Bridger H; Yang, Bosco Seong Kyu; Ting, Shun-Ming; Suh, Alexander K; Savarraj, Jude Pj; Huang, Shuning; Körbelin, Jakob; Choi, Huimahn Alex; Marrelli, Sean P; Aronowski, Jaroslaw; Chen, Peng Roc; Kim, Eunhee; Park, Eun S

Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism.

反复轻微头部损伤会形成衰老的颅骨骨髓微环境,从而损害大脑代谢。

Devlin Patrick J, Khan Romeesa, Do Trang H, West Bryce E, Korf Janelle M, Guzman Gary U, Tan Chunfeng, Ahn John, Flores Rene, Maniskas Micheal E, Marrelli Sean P, Malovannaya Anna, Underwood Erica, Ritzel Rodney M

Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice.

单细胞分析发现 Ifi27l2a 是小鼠衰老和中风背景下小胶质细胞炎症的基因调节因子

Kim Gab Seok, Harmon Elisabeth, Gutierrez Manuel C, Kim Sodam, Vance Lauren, Burrous Haven, Stephenson Jessica M, Chauhan Anjali, Banerjee Anik, Wise Zachary, Doan Andrea, Ahn John, Wu Ting, Bautista-Garrido Jesus, Lee Juneyoung, Tan Chunfeng, Jung Joo Eun, McCullough Louise D, Wythe Joshua D, Marrelli Sean P

Immature Acta2(R179C/+) smooth muscle cells cause moyamoya-like cerebrovascular lesions in mice prevented by boosting OXPHOS.

未成熟的 Acta2(R179C/+) 平滑肌细胞会导致小鼠出现类似烟雾病的脑血管病变,而增强 OXPHOS 可以预防这种病变

Kaw Anita, Majumder Suravi, Esparza Pinelo Jose E, Wu Ting, Starosolski Zbigniew, Zhou Zhen, Pedroza Albert J, Duan Xueyan, Kaw Kaveeta, Gonzalez Angie D, Sarkar Ripon, Fischbein Michael P, Lorenzi Philip L, Tan Lin, Martinez Sara A, Mahmud Iqbal, Devkota Laxman, Buja L Maximilian, Taegtmeyer Heinrich, Ghaghada Ketan B, Marrelli Sean P, Kwartler Callie S, Milewicz Dianna M

Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery.

无创实时脉冲多普勒法评估小鼠眼动脉血流

Sharina Iraida, Awad Radwa, Cobb Soren, Martin Emil, Marrelli Sean P, Reddy Anilkumar K

Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents

腹膜注射辣椒素类物质(一种非刺激性的TRPV1激动剂)可通过TRPV1激活内脏迷走神经传入纤维,在清醒小鼠中诱发轻度体温过低。

Andersohn, Alexander P; Wu, Ting; Doan, Andrea N; Cantrell, Charles L; Jarret, Robert L; Marrelli, Sean P

Ifi27l2a acts as a cytokine that promotes a pro-inflammatory phenotype in microglia and enhances neuroinflammation.

Ifi27l2a 作为一种细胞因子,可促进小胶质细胞的促炎表型,并增强神经炎症。

Kim Sodam, Burrous Haven, Harmon Elisabeth, Vance Lauren, Wu Ting, Andersohn Alexander, Doan Andrea, Wolocko Darby, Wise Zachary, Kitamura Yuki, Jung Joo Eun, Colpo Gabriela, Couture Lucy, Blixt Frank, McCullough Louise, Marrelli Sean, Kim Gab Seok

E2f1 Overexpression Reduces Aging-Associated DNA Damage in Cultured Cerebral Endothelial Cells and Improves Cognitive Performance in Aged Mice.

E2f1 过表达可减少培养的脑内皮细胞中与衰老相关的 DNA 损伤,并改善老年小鼠的认知能力

Monga Sheelu, Flores Samantha, Blasco-Conesa Maria Pilar, Rahman Syed M, Noh Brian, Peesh Pedram, Ganesh Bhanu Priya, Marrelli Sean P, McCullough Louise D, Moruno-Manchon Jose Felix

Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice

中性粒细胞和中性粒细胞胞外陷阱导致小鼠蛛网膜下腔出血后血管阻塞和迟发性脑缺血

Zeineddine, Hussein A; Hong, Sung-Ha; Peesh, Pedram; Dienel, Ari; Torres, Kiara; Thankamani Pandit, Peeyush; Matsumura, Kanako; Huang, Shuning; Li, Wen; Chauhan, Anjali; Hagan, John P; Marrelli, Sean P; McCullough, Louise D; Blackburn, Spiros L; Aronowski, Jaroslaw; McBride, Devin W

MEK signaling represents a viable therapeutic vulnerability of KRAS-driven somatic brain arteriovenous malformations

MEK信号通路是KRAS驱动的体细胞脑动静脉畸形的一种可行的治疗靶点。

Suarez, Carlos Flores; Harb, Omar Ashraf; Robledo, Ariadna; Largoza, Gabrielle; Ahn, John J; Alley, Emily K; Wu, Ting; Veeraragavan, Surabi; McClugage, Samuel T; Iacobas, Ionela; Fish, Jason E; Kan, Peter T; Marrelli, Sean P; Wythe, Joshua D