日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.

致病性 Tau 突变导致自噬溶酶体功能障碍,从而限制额颞叶痴呆模型中 Tau 的降解。

Mirfakhar Farzaneh S, Marsh Jacob A, Sato Chihiro, Schache Kylie J, Minaya Miguel A, Dolle Roland E, Pak Stephen C, Silverman Gary A, Perlmutter David H, Macauley Shannon L, Karch Celeste M

Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation

整合基因组学和功能分析揭示NINL是tau蛋白聚集的调节因子

Swift, Samantha K; Huang, Guangming; Cochran, J Nicholas; D'Oliveira Albanus, Ricardo; Minaya, Miguel A; Castruita, Patricia A; Zhang, Rui; Miller, Katherine J; Starr, Emma; Galasso, Grant; Marsh, Jacob A; Kao, Aimee W; Harari, Oscar; Yokoyama, Jennifer S; Karch, Celeste M

Replicable generation of rhesus macaque iPSCs for in vitro modeling of genetic frontotemporal dementia

利用可重复方法生成恒河猴诱导多能干细胞,用于体外模拟遗传性额颞叶痴呆

Colwell, Julia C; Maufort, John P; Williams, Kathryn M; Makulec, Allison T; Fiorentino, Melissa V; Metzger, Jeanette M; Simmons, Heather A; Basu, Puja; Malicki, Kerri B; Karch, Celeste M; Marsh, Jacob A; Emborg, Marina E; Schmidt, Jenna K

Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative.

建立体细胞和干细胞库,研究非洲血统对痴呆症的影响:非洲iPSC计划

Maina Mahmoud B, Isah Murtala B, Marsh Jacob A, Muhammad Zaid, Babazau Larema, Idris Abdulrahman Alkhamis, Aladyeva Ekaterina, Miller Nadia, Starr Emma, Miller Katherine J, Lee Scott, Minaya Miguel, Wray Selina, Harari Oscar, Goni Baba W, Serpell Louise C, Karch Celeste M

Evaluating pathogenicity of variants of unknown significance in APP, PSEN1, and PSEN2

评估APP、PSEN1和PSEN2中意义不明变异的致病性

Marsh, Jacob A; Huang, Guangming; Bowling, Kevin; Renton, Alan E; Ziegemeier, Ellen; Ball, Torri; Pottier, Cyril; Cruchaga, Carlos; Day, Gregory S; Bateman, Randall J; Llibre-Guerra, Jorge J; McDade, Eric; Karch, Celeste M

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation

整合基因组学和功能分析揭示NINL是Tau蛋白聚集的调节因子

Swift, Samantha K; Huang, Guangming; Cochran, J Nicholas; Minaya, Miguel A; Castruita, Patricia A; Miller, Katherine J; Starr, Emma; Galasso, Grant; Marsh, Jacob A; Kao, Aimee W; Yokoyama, Jennifer S; Karch, Celeste M

Interaction domains of the UL16 and UL21 tegument proteins of herpes simplex virus.

单纯疱疹病毒 UL16 和 UL21 被膜蛋白的相互作用域

Harper Amy L, Meckes David G Jr, Marsh Jacob A, Ward Michael D, Yeh Pei-Chun, Baird Nicholas L, Wilson Carol B, Semmes O John, Wills John W

Complex mechanisms for the packaging of the UL16 tegument protein into herpes simplex virus.

UL16 被膜蛋白包装到单纯疱疹病毒中的复杂机制

Meckes David G Jr, Marsh Jacob A, Wills John W