日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Causal modelling of gene effects from regulators to programs to traits

从调控因子到程序再到性状的基因效应因果模型

Ota, Mineto; Spence, Jeffrey P; Zeng, Tony; Dann, Emma; Milind, Nikhil; Marson, Alexander; Pritchard, Jonathan K

Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells

系统性地发现原代人CD4+ T细胞中促HIV和抗HIV宿主因子

Rathore, Ujjwal; Dugan, Eli; Thornton, Hunter; Kumar, Vigneshwari Easwar; Dajani, Rama; Burdick, Ryan C; Young, Janet M; Steinhart, Zachary; Lao, Reanna; Delviks-Frankenberry, Krista A; Choi, Wooyoung; Henriques, William S; Echeverria, Ignacia; Dann, Emma; Dureja, Ishaan; Pathak, Nandini; Arce, Maya M; McKetney, Justin; Umhoefer, Jennifer M; Parulekar, Simrun; Schmidt, Ralf; Polacco, Benjamin J; Neidleman, Jason; Montano, Mauricio; Nguyen, Vinh Q; Sali, Andrej; Levy, Jay A; Tenthorey, Jeannette L; Cheng, Yifan; Roan, Nadia R; Swaney, Danielle L; Kaake, Robyn M; Dodgson, Stacie E; Hiatt, Joseph; Pathak, Vinay K; Malik, Harmit S; Krogan, Nevan J; Marson, Alexander

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci

SEED-Selection技术能够高效富集在多个位点编辑过的原代T细胞。

Chang, Christopher R; Vykunta, Vivasvan S; Lee, Jae Hyun J; Li, Ke; Kochendoerfer, Clara; Muldoon, Joseph J; Wang, Charlotte H; Mazumder, Thomas; Sun, Yang; Goodman, Daniel B; Nyberg, William A; Liu, Chang; Allain, Vincent; Rothrock, Allison; Ye, Chun J; Marson, Alexander; Shy, Brian R; Eyquem, Justin

Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy.

利用 CRISPRoff 进行多重表观遗传记忆编辑可增强胶质母细胞瘤对化疗的敏感性

Lin Katie, Zou Christopher, Hubbard Akane, Sengelmann Sasha, Goudy Laine, Wang I-Ching, Sharma Rohit, Pak Joanna, Foster Kyla, Ozawa Tomoko, de Groot John F, Phillips Joanna, Vasudevan Harish N, Raleigh David R, Marson Alexander, Murthy Niren, Gilbert Luke A, Berger Mitchel S, Liu S John

Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials

自体细胞基因疗法中人为引入异质性:首次人体试验的战略考量

Cabanski, Christopher R; Yang, EnJun; Stewart, Mark D; Allen, Jeff D; Connolly, John E; Dugan, Ute; Greenberg, Philip D; Mackall, Crystal L; June, Carl H; Marson, Alexander; Maus, Marcela V; Ribas, Antoni

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells

病毒样颗粒能够对原代人髓系细胞进行靶向基因工程和混合 CRISPR 筛选。

Jung, Hyuncheol; Devant, Pascal; Ching, Carter; Ota, Mineto; Hamilton, Jennifer; Steinhart, Zachary; Ngo, Wayne; Sandoval, Luis; Jung, Jae Hyung; Xu, Da; An, Meirui; Urs, Esha; Chen, Peixin Amy; Allain, Vincent; Tada, Takuya; Nuñez, James K; Landau, Nathaniel R; Liu, David R; Eyquem, Justin; Doudna, Jennifer A; Marson, Alexander; Carnevale, Julia

Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq

从调控因子到程序再到性状的基因效应因果建模:遗传关联和扰动测序的整合

Ota, Mineto; Spence, Jeffrey P; Zeng, Tony; Dann, Emma; Marson, Alexander; Pritchard, Jonathan K

Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function

利用位点特异性基因组工程改造原代人类自然杀伤细胞,使其具备可编程的抗肿瘤功能

Allain, Vincent; Rothrock, Allison G; Bernard, Pierre-Louis; Nyberg, William A; Talbot, Alexis; Muldoon, Joseph J; Chung, Jing-Yi; To, Angela; Chang, Christopher R; Kimmerly, Gabriella R; Liu, Chang; Tsao, Tasha; Mortazavi, Yasaman; Seo, Jin; Li, Zhongmei; Shemesh, Avishai; Schmidt, Ralf; Ward, Carl C; Marson, Alexander; Lanier, Lewis L; Aguilar, Oscar A; Eyquem, Justin

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

对 A20 基因中的单个错义突变进行碱基编辑可增强 CAR-T 细胞的疗效

Blaisdell, Adam; Bachl, Stefanie; Sandoval, Luis R; Ching, Carter; Bowman, Christopher J; Kale, Nupura; Prabandham, Manu; Diolaiti, Morgan; Havig, Claire; Advincula, Rommel; Lenci, Nika; Li, Zhongmei; Yamashita, Emily; Wang, Charlotte H; Zhang, Shimin; Liu, Qi; Achacoso, Philip; Stibor, Dorothea; Øynebråten, Inger; Seo, Jin; Ashworth, Alan; Marson, Alexander; Ye, Chun Jimmie; Malynn, Barbara A; Eyquem, Justin; Carnevale, Julia; Ma, Averil

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors.

利用体内全基因组 CRISPR 筛选人类 T 细胞,以增强 T 细胞疗法对实体瘤的疗效。

Liu Qi, Chen Peixin Amy, Urs Esha, Zhang Shimin, Arce Maya M, Wang Charlotte H, Li Zhongmei, Seo Jin, Kale Nupura, LaFlam Taylor N, Peng Fanglue, Shifrut Eric, Allen Greg M, Eyquem Justin, Fuh Katherine, Dodgson Stacie E, Cyster Jason G, Marson Alexander, Carnevale Julia