日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.

VHL募集嵌合体通过化学方法诱导内质网应激传感器IRE1的降解。

Du Jin, Villemure Elisia, Johnson Matthew, Azumaya Caleigh, Gaspar Catarina J, Marsters Scot, Lawrence David, Foster Scott, Rohou Alexis, Cheung Tommy K, Rose Christopher M, Garner Thomas, Ro Soo, Clark Kevin, Beresini Maureen H, Braun Marie-Gabrielle, Rudolph Joachim, Hsu Peter, Ashkenazi Avi

Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells.

干扰素调节因子 4 介导多发性骨髓瘤细胞中非酶促 IRE1 依赖性

Oikonomidi Ioanna, Kameswaran Vasumathi, Pham Victoria C, Zuazo-Gaztelu Iratxe, Gutgesell Lauren M, Marsters Scot, Daniel Bence, Lill Jennie R, Modrusan Zora, Ashkenazi Avi

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth.

对肌醇需求酶 1 的非酶促依赖性控制着癌细胞周期进程和肿瘤生长

Zuazo-Gaztelu Iratxe, Lawrence David, Oikonomidi Ioanna, Marsters Scot, Pechuan-Jorge Ximo, Gaspar Catarina J, Kan David, Segal Ehud, Clark Kevin, Beresini Maureen, Braun Marie-Gabrielle, Rudolph Joachim, Modrusan Zora, Choi Meena, Sandoval Wendy, Reichelt Mike, DeWitt David C, Kujala Pekka, van Dijk Suzanne, Klumperman Judith, Ashkenazi Avi

IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment

IRE1α在三阴性乳腺癌中的破坏通过逆转内质网应激适应和重塑肿瘤微环境与抗血管生成疗法协同作用

Harnoss, Jonathan M; Le Thomas, Adrien; Reichelt, Mike; Guttman, Ofer; Wu, Thomas D; Marsters, Scot A; Shemorry, Anna; Lawrence, David A; Kan, David; Segal, Ehud; Merchant, Mark; Totpal, Klara; Crocker, Lisa M; Mesh, Kathryn; Dohse, Monika; Solon, Margaret; Modrusan, Zora; Rudolph, Joachim; Koeppen, Hartmut; Walter, Peter; Ashkenazi, Avi

Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey

抗治疗抗体介导的重组人Apo2L/TRAIL在食蟹猴中的肝毒性

Zuch de Zafra, Christina L; Ashkenazi, Avi; Darbonne, Walter C; Cheu, Melissa; Totpal, Klara; Ortega, Shirley; Flores, Heather; Walker, Mark D; Kabakoff, Bruce; Lum, Bert L; Mounho-Zamora, Barbara J; Marsters, Scot A; Dybdal, Noël O

Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.

Gab1 和 Grb2 衔接蛋白在相关受体酪氨酸激酶 RON 和 MET 的信号转导中发挥着不同的作用

Chaudhuri Amitabha, Xie Ming-Hong, Yang Becky, Mahapatra Kaushiki, Liu Jinfeng, Marsters Scot, Bodepudi Sweta, Ashkenazi Avi