日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I

5,7-二甲氧基色满-3-基 4-甲氧基苯甲酸酯通过肌钙蛋白 I 的磷酸化作用,对突变心肌细丝功能和动力学的调节具有独特的影响

Yang, Zeyu; Sheehan, Alice M; Papadaki, Mary; Messer, Andrew E; Blagg, Brian S J; Gould, Ian R; Marston, Steven B

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

营养保健品水飞蓟宾B、白藜芦醇和表没食子儿茶素-3-没食子酸酯与心肌肌钙蛋白结合,可在体外、体内和计算机模拟中恢复由心肌病突变引起的舒张功能丧失。

Yang, Zeyu; Sheehan, Alice M; Messer, Andrew E; Tsui, Sharmane; Sparrow, Alexander; Redwood, Charles; Kren, Vladimir; Gould, Ian R; Marston, Steven B

Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics

自上而下蛋白质组学研究揭示,不同的肥厚型心肌病基因型导致趋同的肌节蛋白异构体谱。

Tucholski, Trisha; Cai, Wenxuan; Gregorich, Zachery R; Bayne, Elizabeth F; Mitchell, Stanford D; McIlwain, Sean J; de Lange, Willem J; Wrobbel, Max; Karp, Hannah; Hite, Zachary; Vikhorev, Petr G; Marston, Steven B; Lal, Sean; Li, Amy; Dos Remedios, Cristobal; Kohmoto, Takushi; Hermsen, Joshua; Ralphe, J Carter; Kamp, Timothy J; Moss, Richard L; Ge, Ying

Investigations into the Sarcomeric Protein and Ca(2+)-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

对猫(Felix catus)肥厚型心肌病肌节蛋白和 Ca(2+) 调节异常的研究

Messer Andrew E, Chan Jasmine, Daley Alex, Copeland O'Neal, Marston Steven B, Connolly David J

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function

原肌球蛋白必须与肌动蛋白弱相互作用才能有效调节细丝功能

Rynkiewicz, Michael J; Prum, Thavanareth; Hollenberg, Stephen; Kiani, Farooq A; Fagnant, Patricia M; Marston, Steven B; Trybus, Kathleen M; Fischer, Stefan; Moore, Jeffrey R; Lehman, William

A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation

心肌梗死后权力斗争:心肌力量的适应性变化发生在肌节水平,伴随MyBP-C和RLC磷酸化。

Toepfer, Christopher N; Sikkel, Markus B; Caorsi, Valentina; Vydyanath, Anupama; Torre, Iratxe; Copeland, O'Neal; Lyon, Alexander R; Marston, Steven B; Luther, Pradeep K; Macleod, Kenneth T; West, Timothy G; Ferenczi, Michael A

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.

与肥厚型心肌病相关的肌钙蛋白 T 突变会增加 Ca(2+) 敏感性,并抑制肌钙蛋白 I 磷酸化对 Ca(2+) 敏感性的调节

Messer Andrew E, Bayliss Christopher R, El-Mezgueldi Mohammed, Redwood Charles S, Ward Douglas G, Leung Man-Ching, Papadaki Maria, Dos Remedios Cristobal, Marston Steven B

Instrumentation to study myofibril mechanics from static to artificial simulations of cardiac cycle

用于研究肌原纤维力学的仪器,涵盖从静态到心动周期人工模拟的各个阶段。

Vikhorev, Petr G; Ferenczi, Michael A; Marston, Steven B

Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate.

肌丝 Ca2+ 敏感性与肌钙蛋白 I 磷酸化之间的突变解偶联可通过表没食子儿茶素-3-没食子酸酯逆转

Papadaki Maria, Vikhorev Petr G, Marston Steven B, Messer Andrew E

The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I

导致扩张型心肌病的ACTC E361G突变存在于心肌肌原纤维中,特异性地消除了肌钙蛋白I磷酸化对Ca(2+)调节的调控作用。

Vikhorev, Petr G; Song, Weihua; Wilkinson, Ross; Copeland, O'Neal; Messer, Andrew E; Ferenczi, Michael A; Marston, Steven B