日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity

治疗性抗体内化进入树突状细胞是免疫原性的危险因素

Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katharina Hartman, Cary M Looney, Olivier Rohr, Timothy P Hickling, Hubert Kettenberger, Martin Lechmann, Céline Marban-Doran #, Thomas E Kraft #

ROCKETS - a novel one-for-all toolbox for light sheet microscopy in drug discovery

ROCKETS——一款用于药物发现的光片显微镜通用工具箱

Joerg P J Mueller ,Michael Dobosz ,Nils O'Brien ,Nassri Abdoush ,Anna Maria Giusti ,Martin Lechmann ,Franz Osl ,Ann-Katrin Wolf ,Estibaliz Arellano-Viera ,Haroon Shaikh ,Markus Sauer ,Andreas Rosenwald ,Frank Herting ,Pablo Umaña ,Sara Colombetti ,Thomas Pöschinger ,Andreas Beilhack

Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

成纤维细胞活化蛋白 α 靶向 CD40 激动剂可消除全身毒性,并能通过高剂量给药诱导有效的抗肿瘤免疫

Eva Sum #, Moritz Rapp #, Philipp Fröbel, Marine Le Clech, Harald Dürr, Anna Maria Giusti, Mario Perro, Dario Speziale, Leo Kunz, Elena Menietti, Peter Brünker, Ulrike Hopfer, Martin Lechmann, Andrzej Sobieniecki, Birte Appelt, Roberto Adelfio, Valeria Nicolini, Anne Freimoser-Grundschober, Whitney

The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

免疫原性对治疗性抗体药代动力学的影响:免疫复合物形成和抗体效应功能对清除率影响的临床前评估

Eugenia Opolka-Hoffmann, Gregor Jordan, Michael Otteneder, Robin Kieferle, Martin Lechmann, Gerhard Winter, Roland F Staack

Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection

丙型肝炎病毒样颗粒免疫可保护小鼠免受重组丙型肝炎病毒-痘苗感染

Kazumoto Murata, Martin Lechmann, Ming Qiao, Toshiaki Gunji, Harvey J Alter, T Jake Liang