日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A streamlined base editor engineering strategy to reduce bystander editing

精简基础编辑器工程策略,以减少旁观者编辑

Izabella Valdez ,Ian O'Connor ,Divesh Patel ,Katherine Gierer ,Jan Harrington ,Ethan Ellis ,Stephen A Caponetti ,Robert P Sebra ,Hillary C Valley ,Kevin Coote ,Martin Mense ,Samuele G Marro ,Tingting Jiang

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway

含有无义密码子的 CFTR mRNA 被 SMG6 介导的内切酶降解途径降解

Edward J Sanderlin, Melissa M Keenan, Martin Mense, Alexey S Revenko, Brett P Monia, Shuling Guo, Lulu Huang

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

对囊性纤维化气道进行单细胞分辨率的转录组分析揭示了上皮细胞状态和组成的改变

Gianni Carraro # ,Justin Langerman # ,Shan Sabri ,Zareeb Lorenzana ,Arunima Purkayastha ,Guangzhu Zhang ,Bindu Konda ,Cody J Aros ,Ben A Calvert ,Aleks Szymaniak ,Emily Wilson ,Michael Mulligan ,Priyanka Bhatt ,Junjie Lu ,Preethi Vijayaraj ,Changfu Yao ,David W Shia ,Andrew J Lund ,Edo Israely ,Tammy M Rickabaugh ,Jason Ernst ,Martin Mense ,Scott H Randell ,Eszter K Vladar ,Amy L Ryan ,Kathrin Plath ,John E Mahoney ,Barry R Stripp ,Brigitte N Gomperts

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

腺嘌呤碱基编辑器mRNA和引导RNA的化学修饰拓展了其应用范围

Tingting Jiang, Jordana M Henderson, Kevin Coote, Yi Cheng, Hillary C Valley, Xiao-Ou Zhang, Qin Wang, Luke H Rhym, Yueying Cao, Gregory A Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G Anderson, Anton P McCaffrey, David R Liu, Wen Xue

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

修订后的气道上皮细胞层级结构包括表达CFTR的离子细胞。

Daniel T Montoro,Adam L Haber,Moshe Biton,Vladimir Vinarsky,Brian Lin,Susan E Birket,Feng Yuan,Sijia Chen,Hui Min Leung,Jorge Villoria,Noga Rogel,Grace Burgin,Alexander M Tsankov,Avinash Waghray,Michal Slyper,Julia Waldman,Lan Nguyen,Danielle Dionne,Orit Rozenblatt-Rosen,Purushothama Rao Tata,Hongmei Mou,Manjunatha Shivaraju,Hermann Bihler,Martin Mense,Guillermo J Tearney,Steven M Rowe,John F Engelhardt,Aviv Regev,Jayaraj Rajagopal

Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule

通过双作用小分子部分挽救 F508del-囊性纤维化跨膜传导调节通道门控,适度改善蛋白质加工,但不改善稳定性

Jia Liu, Hermann Bihler, Carlos M Farinha, Nikhil T Awatade, Ana M Romão, Dayna Mercadante, Yi Cheng, Isaac Musisi, Walailak Jantarajit, Yiting Wang, Zhiwei Cai, Margarida D Amaral, Martin Mense, David N Sheppard

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells

双重 SMAD 信号抑制可实现多种上皮基底细胞的长期扩增

Hongmei Mou, Vladimir Vinarsky, Purushothama Rao Tata, Karissa Brazauskas, Soon H Choi, Adrianne K Crooke, Bing Zhang, George M Solomon, Brett Turner, Hermann Bihler, Jan Harrington, Allen Lapey, Colleen Channick, Colleen Keyes, Adam Freund, Steven Artandi, Martin Mense, Steven Rowe, John F Engelhar

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations

发现经临床批准的促进抑制囊性纤维化跨膜传导调节器无义突变的药物

Venkateshwar Mutyam, Ming Du, Xiaojiao Xue, Kim M Keeling, E Lucile White, J Robert Bostwick, Lynn Rasmussen, Bo Liu, Marina Mazur, Jeong S Hong, Emily Falk Libby, Feng Liang, Haibo Shang, Martin Mense, Mark J Suto, David M Bedwell, Steven M Rowe

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

CFTR 的体内磷酸化促进核苷酸结合域异二聚体的形成

Martin Mense, Paola Vergani, Dennis M White, Gal Altberg, Angus C Nairn, David C Gadsby