日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TRBC1-CAR T cell therapy in peripheral T cell lymphoma: a phase 1/2 trial

TRBC1-CAR T细胞疗法治疗外周T细胞淋巴瘤:一项1/2期试验

Kate Cwynarski ,Gloria Iacoboni ,Eleni Tholouli ,Tobias Menne ,David A Irvine ,Nivetha Balasubramaniam ,Leigh Wood ,Justin Shang ,Eric Xue ,Yiyun Zhang ,Silvia Basilico ,Margarida Neves ,Meera Raymond ,Ian Scott ,Mohamed El-Kholy ,Ram Jha ,Heather Dainton-Smith ,Rehan Hussain ,William Day ,Mathieu Ferrari ,Simon Thomas ,Koki Lilova ,Wolfram Brugger ,Teresa Marafioti ,Pierre Lao-Sirieix ,Paul Maciocia ,Martin Pule

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

针对T细胞恶性肿瘤中TRBC1和TRBC2的结构导向免疫疗法工程

Mathieu Ferrari # ,Matteo Righi # ,Vania Baldan ,Patrycja Wawrzyniecka ,Anna Bulek ,Alexander Kinna ,Biao Ma ,Reyisa Bughda ,Zulaikha Akbar ,Saket Srivastava ,Isaac Gannon ,Mathew Robson ,James Sillibourne ,Ram Jha ,Mohamed El-Kholy ,Oliver Muhammad Amin ,Evangelia Kokalaki ,Mohammed Amin Banani ,Rehan Hussain ,William Day ,Wen Chean Lim ,Priyanka Ghongane ,Jade R Hopkins ,Dennis Jungherz ,Marco Herling ,Martin Welin ,Sachin Surade ,Michael Dyson ,John McCafferty ,Derek Logan ,Shaun Cordoba ,Simon Thomas ,Andrew Sewell ,Paul Maciocia ,Shimobi Onuoha ,Martin Pule

Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein-Protein Interaction

基于米诺环素诱导的蛋白质-蛋白质相互作用破坏的小分子调控系统

Ram Jha ,Alexander Kinna ,Alastair Hotblack ,Reyisa Bughda ,Anna Bulek ,Isaac Gannon ,Tudor Ilca ,Christopher Allen ,Katarina Lamb ,Abigail Dolor ,Ian Scott ,Farhaan Parekh ,James Sillibourne ,Shaun Cordoba ,Shimobi Onuoha ,Simon Thomas ,Mathieu Ferrari ,Martin Pule

Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia

与白血病儿童中持续存在的 CD19 CAR-T 细胞相关的转录特征

Nathaniel D Anderson, Jack Birch #, Theo Accogli #, Ignacio Criado #, Eleonora Khabirova, Conor Parks, Yvette Wood, Matthew D Young, Tarryn Porter, Rachel Richardson, Sarah J Albon, Bilyana Popova, Andre Lopes, Robert Wynn, Rachael Hough, Satyen H Gohil, Martin Pule, Persis J Amrolia, Sam Behjati, S

Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR

利用新型高灵敏度 aCD22 CAR 双重靶向 CD19 和 CD22 治疗 B 细胞急性淋巴细胞白血病 (B-ALL)。

Evangelia Kokalaki ,Biao Ma ,Mathieu Ferrari ,Thomas Grothier ,Warren Hazelton ,Somayya Manzoor ,Eren Costu ,Julia Taylor ,Anna Bulek ,Saket Srivastava ,Isaac Gannon ,Ram Jha ,Rosalind Gealy ,Lukas Stanczuk ,Tatiana Rizou ,Mathew Robson ,Mohamed El-Kholy ,Vania Baldan ,Matteo Righi ,James Sillibourne ,Simon Thomas ,Shimobi Onuoha ,Shaun Cordoba ,Martin Pule

Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors

利用基于Fab片段的组成型异二聚体细胞因子受体增强CAR T细胞疗法

Matteo Righi ,Isaac Gannon ,Matthew Robson ,Saket Srivastava ,Evangelia Kokalaki ,Thomas Grothier ,Francesco Nannini ,Christopher Allen ,Yuchen V Bai ,James Sillibourne ,Shaun Cordoba ,Simon Thomas ,Martin Pule

Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

新型Fas-TNFR嵌合体可阻止Fas配体介导的细胞杀伤,并协同信号传导以增强CAR-T细胞疗效。

Callum McKenzie ,Mohamed El-Kholy ,Farhaan Parekh ,Mathew Robson ,Katarina Lamb ,Christopher Allen ,James Sillibourne ,Shaun Cordoba ,Simon Thomas ,Martin Pule

Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2

通过表达显性负性SHP1和SHP2来探索T细胞免疫反应

Julia Taylor,Anna Bulek,Isaac Gannon,Mathew Robson,Evangelia Kokalaki,Thomas Grothier,Callum McKenzie,Mohamed El-Kholy,Maria Stavrou,Charlotte Traynor-White,Wen Chean Lim,Panagiota Panagiotou,Saket Srivastava,Vania Baldan,James Sillibourne,Mathieu Ferrari,Martin Pule,Simon Thomas

Large-scale manufacturing of base-edited chimeric antigen receptor T cells

大规模生产碱基编辑的嵌合抗原受体T细胞

Rosie Woodruff, Farhaan Parekh, Katarina Lamb, Leila Mekkaoui, Christopher Allen, Katerina Smetanova, Jasmine Huang, Alex Williams, Gerardo Santiago Toledo, Koki Lilova, Claire Roddie, James Sillibourne, Martin Pule

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

针对复发或难治性B细胞急性淋巴细胞白血病患儿及青少年患者的CD19和CD22双重靶向CAR-T细胞:一项I期临床试验

Shaun Cordoba # ,Shimobi Onuoha # ,Simon Thomas # ,Daniela Soriano Pignataro ,Rachael Hough ,Sara Ghorashian ,Ajay Vora ,Denise Bonney ,Paul Veys ,Kanchan Rao ,Giovanna Lucchini ,Robert Chiesa ,Jan Chu ,Liz Clark ,Mei Mei Fung ,Koval Smith ,Carlotta Peticone ,Muhammad Al-Hajj ,Vania Baldan ,Mathieu Ferrari ,Saket Srivastava ,Ram Jha ,Frederick Arce Vargas ,Kevin Duffy ,William Day ,Paul Virgo ,Lucy Wheeler ,Jeremy Hancock ,Farzin Farzaneh ,Sabine Domning ,Yiyun Zhang ,Nushmia Z Khokhar ,Vijay G R Peddareddigari ,Robert Wynn ,Martin Pule ,Persis J Amrolia