日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.

新型持续性钠电流抑制剂 PRAX-562 具有强效抗惊厥活性,与标准钠通道阻滞剂相比,其保护指数有所提高

Kahlig Kristopher M, Scott Liam, Hatch Robert J, Griffin Andrew, Martinez Botella Gabriel, Hughes Zoë A, Wittmann Marion

Discovery of the First Orally Available, Selective K(Na)1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

首个口服选择性K(Na)1.1抑制剂的发现:恶二唑系列化合物的体外和体内活性

Griffin, Andrew M; Kahlig, Kristopher M; Hatch, Robert John; Hughes, Zoë A; Chapman, Mark L; Antonio, Brett; Marron, Brian E; Wittmann, Marion; Martinez-Botella, Gabriel

Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator

一种新型γ-氨基丁酸A型受体阳性变构调节剂可挽救脆性X综合征Fmr-/y小鼠模型中杏仁核张力性γ-氨基丁酸能电流的不足

Martin, Brandon S; Martinez-Botella, Gabriel; Loya, Carlos M; Salituro, Francesco G; Robichaud, Albert J; Huntsman, Molly M; Ackley, Mike A; Doherty, James J; Corbin, Joshua G