Martinez-Ledesma相关文献与解析，生知库 | 链接生命科学的每一步

Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma

神经元分化驱动丝裂原活化蛋白激酶激酶 (MEK) 抑制在胶质母细胞瘤中的抗肿瘤活性

Sabbir Khan, Emmanuel Martinez-Ledesma, Jianwen Dong, Rajasekaran Mahalingam, Soon Young Park, Yuji Piao, Dimpy Koul, Veerakumar Balasubramaniyan, John F de Groot, W K Alfred Yung

神经

Epigenetics of neural differentiation: Spotlight on enhancers

神经分化的表观遗传学：聚焦增强子

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2022.1001701

Giacoman-Lozano, Mayela; Meléndez-Ramírez, César; Martinez-Ledesma, Emmanuel; Cuevas-Diaz Duran, Raquel; Velasco, Iván

DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review

DNA修复基因作为拉丁美洲早期乳腺癌候选药物的研究：系统性综述

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms222313030

Urbina-Jara, Laura Keren; Martinez-Ledesma, Emmanuel; Rojas-Martinez, Augusto; Rodriguez-Recio, Francisco Ricardo; Ortiz-Lopez, Rocio

Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells

内在干扰素信号调节胶质母细胞瘤干细胞的细胞死亡和间充质表型

期刊:Cancers

影响因子:

doi:10.3390/cancers13215284

Sabbir Khan, Rajasekaran Mahalingam, Shayak Sen, Emmanuel Martinez-Ledesma, Arshad Khan, Kaitlin Gandy, Frederick F Lang, Erik P Sulman, Kristin D Alfaro-Munoz, Nazanin K Majd, Veerakumar Balasubramaniyan, John F de Groot

Computational methods for detecting cancer hotspots

用于检测癌症热点的计算方法

期刊:Computational and Structural Biotechnology Journal

影响因子:4.1

doi:10.1016/j.csbj.2020.11.020

Martinez-Ledesma, Emmanuel; Flores, David; Trevino, Victor

Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors

CLK2 的消耗使胶质瘤干细胞样细胞对 PI3K/mTOR 和 FGFR 抑制剂敏感

期刊:

影响因子:3.6

doi:

Soon Young Park, Sandeep Mittal, Jianwen Dong, Kangjin Jeong, Emmanuel Martinez-Ledesma, Yuji Piao, Sabbir Khan, Verlene Henry, Roel Gw Verhaak, Nazanin Majd, Veerakumar Balasubramaniyan, John F de Groot

Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors

CLK2 的缺失会使胶质瘤干细胞样细胞对 PI3K/mTOR 和 FGFR 抑制剂更加敏感

期刊:

影响因子:3.6

doi:PMC7716149

Soon Young Park，Sandeep Mittal，Jianwen Dong，Kangjin Jeong，Emmanuel Martinez-Ledesma，Yuji Piao，Sabbir Khan，Verlene Henry，Roel Gw Verhaak，Nazanin Majd，Veerakumar Balasubramaniyan，John F de Groot

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Buparlisib 治疗具有磷脂酰肌醇 3-激酶通路激活的复发性胶质母细胞瘤患者：一项开放标签、多中心、多组 II 期试验

期刊:Journal of Clinical Oncology

影响因子:42.1

doi:10.1200/JCO.18.01207

Patrick Y Wen, Mehdi Touat, Brian M Alexander, Ingo K Mellinghoff, Shakti Ramkissoon, Christine S McCluskey, Kristine Pelton, Sam Haidar, Sankha S Basu, Sarah C Gaffey, Loreal E Brown, Juan Emmanuel Martinez-Ledesma, Shaofang Wu, Jungwoo Kim, Wei Wei, Mi-Ae Park, Jason T Huse, John G Kuhn, Mikael L

BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening

使用基于 shRNA 的高通量合成致死筛选，BRCA1 被鉴定为 P53 野生型 GBM 中替莫唑胺耐药性的调节因子

期刊:

影响因子:3.6

doi:

Jie Ding, Shaofang Wu, Chen Zhang, Arnav Garyali, Emmanuel Martinez-Ledesma, Feng Gao, Adarsha Pokkulandra, Xiaolong Li, Christopher Bristow, Alessandro Carugo, Dimpy Koul, Wk Alfred Yung

信号转导

发表日期：2019

文献求助收藏

Genotype subtyping approach to identify unnoticed variants in diseases from GWAS data

利用基因型亚型分析方法从全基因组关联研究（GWAS）数据中识别疾病中未被发现的变异

Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma

神经元分化驱动丝裂原活化蛋白激酶激酶 (MEK) 抑制在胶质母细胞瘤中的抗肿瘤活性

Epigenetics of neural differentiation: Spotlight on enhancers

神经分化的表观遗传学：聚焦增强子

DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review

DNA修复基因作为拉丁美洲早期乳腺癌候选药物的研究：系统性综述

Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells

内在干扰素信号调节胶质母细胞瘤干细胞的细胞死亡和间充质表型

Computational methods for detecting cancer hotspots

用于检测癌症热点的计算方法

Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors

CLK2 的消耗使胶质瘤干细胞样细胞对 PI3K/mTOR 和 FGFR 抑制剂敏感

Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors

CLK2 的缺失会使胶质瘤干细胞样细胞对 PI3K/mTOR 和 FGFR 抑制剂更加敏感

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Buparlisib 治疗具有磷脂酰肌醇 3-激酶通路激活的复发性胶质母细胞瘤患者：一项开放标签、多中心、多组 II 期试验

BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening

使用基于 shRNA 的高通量合成致死筛选，BRCA1 被鉴定为 P53 野生型 GBM 中替莫唑胺耐药性的调节因子