日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression

MDM2 抑制剂通过增强 NFI 表达,与缺乏 E1B55kDa 基因的腺病毒一起对野生型 p53 间皮瘤产生协同细胞毒作用

Thao Thi Thanh Nguyen, Masato Shingyoji, Michiko Hanazono, Boya Zhong, Takao Morinaga, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa2

AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression

培美曲塞治疗细胞中诱导的 AMPK 激活与药物耐药性的产生有关,与靶酶表达无关

Yiyang Qin, Ikuo Sekine, Michiko Hanazono, Takao Morinaga, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Naoto Yamaguchi, Masatoshi Tagawa

Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity

热休克蛋白 90 抑制剂可增强内源性野生型 p53 表达,但通过抑制蛋白酶体活性来下调腺病毒诱导的表达

Kuan Chai, Xuerao Ning, Thảo Thi Thanh Nguyễn, Boya Zhong, Takao Morinaga, Zhihan Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi, Masatoshi Tagawa

Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells

培美曲塞可诱导心脏锚蛋白重复序列表达增强,这可能是间皮瘤细胞对培美曲塞耐药性的潜在标志物。

Yiyang Qin ,Ikuo Sekine ,Mengmeng Fan ,Yuichi Takiguchi ,Yuji Tada ,Masato Shingyoji ,Michiko Hanazono ,Naoto Yamaguchi ,Masatoshi Tagawa

An image cytometric technique is a concise method to detect adenoviruses and host cell proteins and to monitor the infection and cellular responses induced

图像细胞计数技术是一种检测腺病毒和宿主细胞蛋白并监测感染和细胞反应的简便方法

Takao Morinaga, Thảo Thi Thanh Nguyễn, Boya Zhong, Michiko Hanazono, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

由外源调控区驱动的复制型腺病毒的细胞毒性与病毒感染性/基因表达或 E1A 激活能力并无线性相关性,但与 p53 基因型有关

Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways

二甲双胍与 nutlin-3a 联合作用,通过 mTOR 和 p53 通路间的相互作用,对恶性间皮瘤产生生长抑制作用

Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi, Masatoshi Tagawa

Fas ligand DNA enhances a vaccination effect by coadministered DNA encoding a tumor antigen through augmenting production of antibody against the tumor antigen

Fas 配体 DNA 通过与编码肿瘤抗原的 DNA 共同给药,增强针对肿瘤抗原的抗体产生,从而增强疫苗接种效果

Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa