日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

通过基于片段的抑制剂先导化合物发现,展现了WRN结构的灵活性

Palte, Rachel L; Mandal, Mihir; Sikorska, Justyna; Villafania, Artjohn B; Rickard, Meredith M; Bauer, Robert J; Buevich, Alexei V; Chai, Xiaomei; He, Jiafang; Hussain, Zahid; Koglin, Markus; MacDonald, Hannah B; Mansueto, My S; Maskos, Klaus; Methot, Joey L; Robustelli, Jaclyn; Soriano, Aileen; Tauchert, Marcel J; Tyagarajan, Sriram; Zhang, Minjia; Klein, Daniel J; Hicks, Jacqueline D; McLaren, David G; Gabelli, Sandra B; Wyss, Daniel F

A Cre-dependent lentiviral vector for neuron subtype-specific expression of large proteins

一种用于神经元亚型特异性表达大蛋白的Cre依赖性慢病毒载体

Xue, Weixuan; Picaud, Sandrine; Hepp, Régine; Pons, Stéphanie; Maskos, Uwe; Lambolez, Bertrand; Tricoire, Ludovic

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors.

尼古丁通过 VTA-NAc 反馈回路抑制投射到杏仁核的多巴胺神经元,从而诱发焦虑样行为

Le Borgne Tïnaïg, Nguyen Claire, Vicq Eléonore, Jehl Joachim, Solié Clément, Guyon Nicolas, Daussy Louison, Gulmez Aylin, Reynolds Lauren M, Mondoloni Sarah, Tolu Stéfania, Pons Stéphanie, Maskos Uwe, Valjent Emmanuel, Mourot Alexandre, Faure Philippe, Marti Fabio

The interpeduncular nucleus blunts the rewarding effect of nicotine.

脚间核减弱了尼古丁的奖赏效应

Jehl Joachim, Ciscato Maria, Vicq Eléonore, Guyon Nicolas, Dejean de la Batie Gabrielle, Mondoloni Sarah, Frangieh Jacinthe, Mohayyaei Monir, Nguyen Claire, Pons Stéphanie, Maskos Uwe, Hardelin Jean-Pierre, Marti Fabio, Corringer Pierre-Jean, Faure Philippe, Mourot Alexandre

Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6

将神经元和突触特性的改变与尼古丁受体α5亚基基因功能障碍联系起来:大鼠mPFC和人类皮层第6层的转化研究

Yang, Danqing; Qi, Guanxiao; Delev, Daniel; Maskos, Uwe; Feldmeyer, Dirk

The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans

CHRNA5 和 D398N 错义变异对啮齿动物和人类社会及情感行为的影响

de Chaumont, F; Icick, R; Gorwood, P; Granon, S; Forget, B; Bouarab, C; Mattioni, J; Bourgeron, T; Maskos, U; Ramoz, N; Besson, M

The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1

桥联苯并氮杂卓酰胺作为RIPK1选择性变构调节剂的发现

Chen, Joanna L; Methot, Joey L; Mitcheltree, Matthew J; Musacchio, Andrew; Corcoran, Emily B; Feng, Guo; Lammens, Alfred; Maskos, Klaus; Palte, Rachel L; Rickard, Meredith M; Otte, Karin M; Mansueto, My S; Venkat, Sriraman; Sondey, Christopher; Thomsen, Maren; Lesburg, Charles A; Fradera, Xavier; Fell, Matthew J; DiMauro, Erin F; Siliphaivanh, Phieng

Allosteric targeting of RIPK1: discovery of novel inhibitors via parallel virtual screening and structure-guided optimization

RIPK1的变构靶向:通过并行虚拟筛选和结构导向优化发现新型抑制剂

Vijayan, R S K; Hamilton, Matthew M; Pfaffinger, Dana E; Alvarez, Fernando G; Reyna, Naphtali J; Bardenhagen, Jennifer P; Shepard, Hannah; Rodriguez, Christian; Goodwani, Sunil; Lightfoot, Yaima; Maskos, Klaus; Johannsson, Sven; Kempf, Georg; Xu, Quanyun Alan; Neumann, Lars; Jiang, Yongying; Do, Mary Geck; Jones, Philip; Lewis, Richard T; Ray, William J; Cross, Jason B

Accelerometer-derived movement features as predictive biomarkers for muscle atrophy in neurocritical care: a prospective cohort study

加速度计衍生的运动特征作为神经重症监护中肌肉萎缩的预测生物标志物:一项前瞻性队列研究

Schmidbauer, Moritz L; Putz, Timon; Gehri, Leon; Ratkovic, Luka; Maskos, Andreas; Zibold, Julia; Bauchmüller, Johanna; Imhof, Sophie; Weig, Thomas; Wuehr, Max; Dimitriadis, Konstantinos

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons

不同的Chrna5基因突变将过量饮酒与I/II型易感性特征和IPN GABA能神经元联系起来

Tochon, Léa; Henkous, Nadia; Besson, Morgane; Maskos, Uwe; David, Vincent