Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter
雌激素和孕酮通过 c-Jun/c-Fos/雌激素受体(孕酮受体)复合物组装到远端调控元件上,诱导转录去抑制,并将细胞周期蛋白 D1 募集到其自身的基因启动子上,从而促进 G1 期间 CCND1 基因的持续激活
期刊:Molecular and Cellular Biology
影响因子:3.2
doi:10.1128/MCB.24.16.7260-7274.2004
Luigi Cicatiello, Raffaele Addeo, Annarita Sasso, Lucia Altucci, Valeria Belsito Petrizzi, Raphaelle Borgo, Massimo Cancemi, Simona Caporali, Silvana Caristi, Claudio Scafoglio, Diana Teti, Francesco Bresciani, Bruno Perillo, Alessandro Weisz