日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Polθ 活性调节 DNMT3A 缺陷型白血病对标准疗法的敏感性。

Le Bac Viet, Vekariya Umeshkumar, Toma Monika M, Nieborowska-Skorska Margaret, Caron Marie-Christine, Gozdecka Malgorzata, Haydar Zayd, Walsh Martin, Ghosh Jayashri, Vaughan-Williams Elaine, Podszywalow-Bartnicka Paulina, Kukuyan Anna-Mariya, Ziolkowska Sylwia, Atkins Jessica, Hadzijusufovic Emir, Chandramouly Gurushankar, Nejati Reza, Piwocka Katarzyna, Pomerantz Richard, Vassiliou George S, Huntly Brian J P, Valent Peter, Wasik Mariusz, Bellacosa Alfonso, Masson Jean-Yves, Gupta Gaorav P, Challen Grant A, Skorski Tomasz

Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cycles

靶向DHODH揭示了AR阳性和AR阴性前列腺癌细胞通过嘧啶合成以及与TCA循环和尿素循环的代谢串扰而存在的代谢脆弱性。

Labroy, Maxime; Paré, Marc-Oliver; Berthiaume, Line; Thomas, Mélissa; Jobin, Cynthia; Veilleux, Alain; Pelletier, Martin; Pouliot, Frédéric; Masson, Jean-Yves; Audet-Walsh, Étienne

The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers.

与遗传性乳腺癌和卵巢癌有关的罕见候选种系 BRIP1/FANCJ 变异的遗传和分子分析。

Alenezi Wejdan M, Milano Larissa, Fierheller Caitlin T, Serruya Corinne, Revil Timothée, Oros Kathleen K, Bruce Jeffrey P, Spiegelman Dan, Pugh Trevor, Mes-Masson Anne-Marie, Provencher Diane, Foulkes William D, El Haffaf Zaki, Rouleau Guy, Bouchard Luigi, Greenwood Celia M T, Ragoussis Jiannis, Masson Jean-Yves, Tonin Patricia N

PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.

PARP1 和 PARylation 通过稳定 CSB-RNAPII 复合物来促进转录偶联的 DNA 修复。

Robu Mihaela, Shah Rashmi G, van den Heuvel Diana, Coulombe Yan, Bazin Marc, van der Woude Melanie, Kragten Angela, Lans Hannes, Pascal John M, Masson Jean-Yves, Luijsterburg Martijn S, Shah Girish M

Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans

MAEA基因的致病性变异会破坏DNA复制叉的稳定性,并与人类发育异常有关。

Zeinali, Elham; Mashayekhi, Fatemeh; Farraj, Rabih Abou; Hasanni, Talah; Caron, Marie-Christine; Coulombe, Yan; Fitieh, Amira; Glover, J N Mark; Masson, Jean-Yves; Ismail, Ismail Hassan

HMCES corrupts replication fork stability during base excision repair in homologous recombination-deficient cells.

HMCES 会破坏同源重组缺陷细胞中碱基切除修复过程中的复制叉稳定性

Peña-Gómez María José, Rodríguez-Martín Yaiza, Del Rio Oliva Marta, Wijesekara Hanthi Yodhara, Berrada Sara, Freire Raimundo, Masson Jean Yves, Reyes José Carlos, Costanzo Vincenzo, Rosado Iván V

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants

ACMG/AMP变异注释指南中关于种系PALB2序列变异分析的规范

Richardson, Marcy E; Bishop, Megan F H; Holdren, Megan A; de la Hoya, Miguel; Spurdle, Amanda B; Tavtigian, Sean V; Brannan, Terra; Young, Colin C; Zec, Lauren; Hiraki, Susan; Turnbull, Clare; Tischkowitz, Marc; Bernstein, Kara A; Masson, Jean-Yves; McNulty, Shannon M; Pesaran, Tina; Monteiro, Alvaro N; Walker, Logan C; Foulkes, William D; Couch, Fergus J

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.

Ski2 解旋酶 ASCC3 在复制叉停滞时解开 DNA,以控制复制压力反应

Cui Shixin, Batenburg Nicole L, Coulombe Yan, Arumugam Aruna, Walker John R, Sheida Sadaf Valeh, Bielinsky Anja-Katrin, Wahl Markus C, Masson Jean-Yves, Zhu Xu-Dong

DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells

DNA聚合酶θ介导的DNA修复是DNMT3A缺陷型白血病细胞的功能依赖性和治疗脆弱性所在。

Le, Bac Viet; Vekariya, Umeshkumar; Toma, Monika M; Nieborowska-Skorska, Margaret; Caron, Marie-Christine; Gozdecka, Malgorzata; Haydar, Zayd; Walsh, Martin; Ghosh, Jayashri; Vaughan-Williams, Elaine; Podszywalow-Bartnicka, Paulina; Kukuyan, Anna-Mariya; Ziolkowska, Sylwia; Hadzijusufovic, Emir; Chandramouly, Gurushankar; Piwocka, Katarzyna; Pomerantz, Richard; Vassiliou, George S; Huntly, Brian Jp; Valent, Peter; Bellacosa, Alfonso; Masson, Jean-Yves; Gupta, Gaorav P; Challen, Grant A; Skorski, Tomasz

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors.

共价和非共价PARylation在维持基因组完整性中的动态过程:以PARP抑制剂为例

Beneyton Adèle, Nonfoux Louis, Gagné Jean-Philippe, Rodrigue Amélie, Kothari Charu, Atalay Nurgul, Hendzel Michael J, Poirier Guy G, Masson Jean-Yves