日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery

PAC-FragmentDEL - 光激活共价捕获 DNA 编码片段以发现目标分子

Huiyong Ma, James B Murray, Huadong Luo, Xuemin Cheng, Qiuxia Chen, Chao Song, Cong Duan, Ping Tan, Lifang Zhang, Jian Liu, Barry A Morgan, Jin Li, Jinqiao Wan, Lisa M Baker, William Finnie, Lucie Guetzoyan, Richard Harris, Nicole Hendrickson, Natalia Matassova, Heather Simmonite, Julia Smith, Roder

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures

通过粗反应混合物的筛选快速优化片段并筛选出先导化合物

Lisa M Baker #, Anthony Aimon #, James B Murray, Allan E Surgenor, Natalia Matassova, Stephen D Roughley, Patrick M Collins, Tobias Krojer, Frank von Delft, Roderick E Hubbard

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

建立抗凋亡蛋白 Bcl-2 和 Mcl-1 的药物发现和热门系列鉴定

James B Murray, James Davidson, Ijen Chen, Ben Davis, Pawel Dokurno, Christopher J Graham, Richard Harris, Allan Jordan, Natalia Matassova, Christopher Pedder, Stuart Ray, Stephen D Roughley, Julia Smith, Claire Walmsley, Yikang Wang, Neil Whitehead, Douglas S Williamson, Patrick Casara, Thierry Le

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

S55746 是一种新型口服 BCL-2 选择性强效抑制剂,可抑制血液肿瘤生长

Patrick Casara #, James Davidson #, Audrey Claperon #, Gaëtane Le Toumelin-Braizat, Meike Vogler, Alain Bruno, Maïa Chanrion, Gaëlle Lysiak-Auvity, Thierry Le Diguarher, Jérôme-Benoît Starck, Ijen Chen, Neil Whitehead, Christopher Graham, Natalia Matassova, Pawel Dokurno, Christopher Pedder, Youzhen

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase

解离速率筛选在鉴定新型丙酮酸脱氢酶激酶泛异构体抑制剂中的应用

Paul A Brough, Lisa Baker, Simon Bedford, Kirsten Brown, Seema Chavda, Victoria Chell, Jalanie D'Alessandro, Nicholas G M Davies, Ben Davis, Loic Le Strat, Alba T Macias, Daniel Maddox, Patrick C Mahon, Andrew J Massey, Natalia Matassova, Sean McKenna, Johannes W G Meissner, Jonathan D Moore, James

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

VER-246608 是一种新型的丙酮酸脱氢酶激酶泛同工酶 ATP 竞争性抑制剂,它能破坏 Warburg 代谢并诱导癌细胞发生依赖于环境的细胞停滞。

Moore, Jonathan D; Staniszewska, Anna; Shaw, Terence; D'Alessandro, Jalanie; Davis, Ben; Surgenor, Alan; Baker, Lisa; Matassova, Natalia; Murray, James; Macias, Alba; Brough, Paul; Wood, Mike; Mahon, Patrick C

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

一种新型 Hsc70/Hsp70 小分子抑制剂可增强 Hsp90 抑制剂诱导的 HCT116 结肠癌细胞凋亡

Andrew J Massey, Douglas S Williamson, Helen Browne, James B Murray, Pawel Dokurno, Terry Shaw, Alba T Macias, Zoe Daniels, Stephanie Geoffroy, Melanie Dopson, Paul Lavan, Natalia Matassova, Geraint L Francis, Christopher J Graham, Rachel Parsons, Yikang Wang, Antony Padfield, Mike Comer, Martin J D

Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors

核糖体RNA是恶唑烷酮类化合物的作用靶点,这是一类新型的翻译抑制剂。

Matassova, N B; Rodnina, M V; Endermann, R; Kroll, H P; Pleiss, U; Wild, H; Wintermeyer, W