日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

多感觉伽马刺激促进淀粉样蛋白的淋巴清除

Mitchell H Murdock, Cheng-Yi Yang, Na Sun, Ping-Chieh Pao, Cristina Blanco-Duque, Martin C Kahn, TaeHyun Kim, Nicolas S Lavoie, Matheus B Victor, Md Rezaul Islam, Fabiola Galiana, Noelle Leary, Sidney Wang, Adele Bubnys, Emily Ma, Leyla A Akay, Madison Sneve, Yong Qian, Cuixin Lai, Michelle M McCart

Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration

人类神经元衰老的纵向模型揭示了 RCAN1-TFEB 通路对亨廷顿病神经变性的贡献

Seong Won Lee #, Young Mi Oh #, Matheus B Victor, Yan Yang, Shawei Chen, Ilya Strunilin, Sonika Dahiya, Roland E Dolle, Stephen C Pak, Gary A Silverman, David H Perlmutter, Andrew S Yoo

An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience

一种对衰老敏感的补偿性分泌性磷脂酶,具有神经保护和认知恢复作用

Cinzia Vicidomini, Travis D Goode, Kathleen M McAvoy, Ruilin Yu, Conor H Beveridge, Sanjay N Iyer, Matheus B Victor, Noelle Leary, Liam Evans, Michael J Steinbaugh, Zon Weng Lai, Marina C Lyon, Manuel Rico F S Silvestre, Gracia Bonilla, Ruslan I Sadreyev, Tobias C Walther, Shannan Ho Sui, Takaomi Sa

Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion

阿尔茨海默病的表观基因组解剖可查明致病变异并揭示表观基因组侵蚀

Xushen Xiong, Benjamin T James, Carles A Boix, Yongjin P Park, Kyriaki Galani, Matheus B Victor, Na Sun, Lei Hou, Li-Lun Ho, Julio Mantero, Aine Ni Scannail, Vishnu Dileep, Weixiu Dong, Hansruedi Mathys, David A Bennett, Li-Huei Tsai, Manolis Kellis

Human microglial state dynamics in Alzheimer's disease progression

阿尔茨海默病进展过程中人类小胶质细胞状态的动态变化

Na Sun,Matheus B Victor,Yongjin P Park,Xushen Xiong,Aine Ni Scannail,Noelle Leary,Shaniah Prosper,Soujanya Viswanathan,Xochitl Luna,Carles A Boix,Benjamin T James,Yosuke Tanigawa,Kyriaki Galani,Hansruedi Mathys,Xueqiao Jiang,Ayesha P Ng,David A Bennett,Li-Huei Tsai,Manolis Kellis

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology

单细胞图谱揭示高认知功能、痴呆和阿尔茨海默病病理恢复力之间的相关性

Hansruedi Mathys, Zhuyu Peng, Carles A Boix, Matheus B Victor, Noelle Leary, Sudhagar Babu, Ghada Abdelhady, Xueqiao Jiang, Ayesha P Ng, Kimia Ghafari, Alexander K Kunisky, Julio Mantero, Kyriaki Galani, Vanshika N Lohia, Gabrielle E Fortier, Yasmine Lotfi, Jason Ivey, Hannah P Brown, Pratham R Pate

Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington's disease

人类神经元老化的纵向模型确定了 RCAN1-TFEB 通路导致亨廷顿氏病的神经退行性病变

Seong Won Lee, Young Mi Oh, Matheus B Victor, Ilya Strunilin, Shawei Chen, Sonika Dahiya, Roland E Dolle, Stephen C Pak, Gary A Silverman, David H Perlmutter, Andrew S Yoo

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

APOE4诱导的脂质积累会损害小胶质细胞对神经元网络活动的监视。

Matheus B Victor ,Noelle Leary ,Xochitl Luna ,Hiruy S Meharena ,Aine Ni Scannail ,P Lorenzo Bozzelli ,George Samaan ,Mitchell H Murdock ,Djuna von Maydell ,Audrey H Effenberger ,Oyku Cerit ,Hsin-Lan Wen ,Liwang Liu ,Gwyneth Welch ,Maeve Bonner ,Li-Huei Tsai

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

神经元中DNA双链断裂会通过类似抗病毒的信号通路激活小胶质细胞,从而导致神经退行性疾病。

Gwyneth M Welch,Carles A Boix,Eloi Schmauch,Jose Davila-Velderrain,Matheus B Victor,Vishnu Dileep,P Lorenzo Bozzelli,Qiao Su,Jemmie D Cheng,Audrey Lee,Noelle S Leary,Andreas R Pfenning,Manolis Kellis,Li-Huei Tsai

Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

体外重建人类血脑屏障揭示APOE4在周细胞中的致病机制

Joel W Blanchard, Michael Bula, Jose Davila-Velderrain, Leyla Anne Akay, Lena Zhu, Alexander Frank, Matheus B Victor, Julia Maeve Bonner, Hansruedi Mathys, Yuan-Ta Lin, Tak Ko, David A Bennett, Hugh P Cam, Manolis Kellis, Li-Huei Tsai