日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

针对T细胞恶性肿瘤中TRBC1和TRBC2的结构导向免疫疗法工程

Mathieu Ferrari # ,Matteo Righi # ,Vania Baldan ,Patrycja Wawrzyniecka ,Anna Bulek ,Alexander Kinna ,Biao Ma ,Reyisa Bughda ,Zulaikha Akbar ,Saket Srivastava ,Isaac Gannon ,Mathew Robson ,James Sillibourne ,Ram Jha ,Mohamed El-Kholy ,Oliver Muhammad Amin ,Evangelia Kokalaki ,Mohammed Amin Banani ,Rehan Hussain ,William Day ,Wen Chean Lim ,Priyanka Ghongane ,Jade R Hopkins ,Dennis Jungherz ,Marco Herling ,Martin Welin ,Sachin Surade ,Michael Dyson ,John McCafferty ,Derek Logan ,Shaun Cordoba ,Simon Thomas ,Andrew Sewell ,Paul Maciocia ,Shimobi Onuoha ,Martin Pule

Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR

利用新型高灵敏度 aCD22 CAR 双重靶向 CD19 和 CD22 治疗 B 细胞急性淋巴细胞白血病 (B-ALL)。

Evangelia Kokalaki ,Biao Ma ,Mathieu Ferrari ,Thomas Grothier ,Warren Hazelton ,Somayya Manzoor ,Eren Costu ,Julia Taylor ,Anna Bulek ,Saket Srivastava ,Isaac Gannon ,Ram Jha ,Rosalind Gealy ,Lukas Stanczuk ,Tatiana Rizou ,Mathew Robson ,Mohamed El-Kholy ,Vania Baldan ,Matteo Righi ,James Sillibourne ,Simon Thomas ,Shimobi Onuoha ,Shaun Cordoba ,Martin Pule

Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

新型Fas-TNFR嵌合体可阻止Fas配体介导的细胞杀伤,并协同信号传导以增强CAR-T细胞疗效。

Callum McKenzie ,Mohamed El-Kholy ,Farhaan Parekh ,Mathew Robson ,Katarina Lamb ,Christopher Allen ,James Sillibourne ,Shaun Cordoba ,Simon Thomas ,Martin Pule

Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2

通过表达显性负性SHP1和SHP2来探索T细胞免疫反应

Julia Taylor,Anna Bulek,Isaac Gannon,Mathew Robson,Evangelia Kokalaki,Thomas Grothier,Callum McKenzie,Mohamed El-Kholy,Maria Stavrou,Charlotte Traynor-White,Wen Chean Lim,Panagiota Panagiotou,Saket Srivastava,Vania Baldan,James Sillibourne,Mathieu Ferrari,Martin Pule,Simon Thomas

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

利用 G-四链体结合小分子靶向胰腺导管腺癌中的多种效应通路

Chiara Marchetti, Katherine G Zyner, Stephan A Ohnmacht, Mathew Robson, Shozeb M Haider, Jennifer P Morton, Giovanni Marsico, Tam Vo, Sarah Laughlin-Toth, Ahmed A Ahmed, Gloria Di Vita, Ingrida Pazitna, Mekala Gunaratnam, Rachael J Besser, Ana C G Andrade, Seckou Diocou, Jeremy A Pike, David Tannahi

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)

聚乙二醇化精氨酸脱亚胺酶(ADI-PEG20)抑制缺氧诱导的一氧化氮生成和肿瘤灌注

Natalie Burrows, Gaelle Cane, Mathew Robson, Edoardo Gaude, William J Howat, Peter W Szlosarek, R Barbara Pedley, Christian Frezza, Margaret Ashcroft, Patrick H Maxwell

Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival

间充质干细胞的致癌转化降低 Nrf2 表达,有利于体内肿瘤生长和较差的存活率

Juan M Funes, Stephen Henderson, Rachel Kaufman, James M Flanagan, Mathew Robson, Barbara Pedley, Salvador Moncada, Chris Boshoff

Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET

开发嘌呤衍生的 18F 标记前体药物示踪剂,用于 PET 对 MRP1 活性进行成像

Eva Galante, Toshimitsu Okamura, Kerstin Sander, Tatsuya Kikuchi, Maki Okada, Ming-Rong Zhang, Mathew Robson, Adam Badar, Mark Lythgoe, Matthias Koepp, Erik Årstad

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

人类 CHCHD4 线粒体蛋白调节细胞耗氧率和代谢,在缺氧信号和肿瘤进展中发挥关键作用

Jun Yang, Oliver Staples, Luke W Thomas, Thomas Briston, Mathew Robson, Evon Poon, Maria L Simões, Ethaar El-Emir, Francesca M Buffa, Afshan Ahmed, Nicholas P Annear, Deepa Shukla, Barbara R Pedley, Patrick H Maxwell, Adrian L Harris, Margaret Ashcroft