日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer

通过 CD3 双特异性和 ADC 方式靶向 CLDN18.2 治疗胃癌和胰腺癌

Guoyun Zhu, Davide Foletti, Xiaohui Liu, Sheng Ding, Jody Melton Witt, Adela Hasa-Moreno, Mathias Rickert, Charles Holz, Laura Aschenbrenner, Amy H Yang, Eugenia Kraynov, Winston Evering, Leslie Obert, Chenyu Lee, Tao Sai, Tina Mistry, Kevin C Lindquist, Thomas Van Blarcom, Pavel Strop, Javier Chapa

Production of soluble and active microbial transglutaminase in Escherichia coli for site-specific antibody drug conjugation

大肠杆菌中生产可溶活性微生物转谷氨酰胺酶用于位点特异性抗体药物结合

Mathias Rickert, Pavel Strop, Victor Lui, Jody Melton-Witt, Santiago Esteban Farias, Davide Foletti, David Shelton, Jaume Pons, Arvind Rajpal

Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

针对 Nav1.7 钠通道设计高效选择性微蛋白用于治疗疼痛

Anatoly Shcherbatko, Andrea Rossi, Davide Foletti, Guoyun Zhu, Oren Bogin, Meritxell Galindo Casas, Mathias Rickert, Adela Hasa-Moreno, Victor Bartsevich, Andreas Crameri, Alexander R Steiner, Robert Henningsen, Avinash Gill, Jaume Pons, David L Shelton, Arvind Rajpal, Pavel Strop

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

啮齿动物血浆中不可裂解的基于 Auristatin 的连接子-有效载荷的位点依赖性降解及其对 ADC 疗效的影响

Magdalena Dorywalska, Pavel Strop, Jody A Melton-Witt, Adela Hasa-Moreno, Santiago E Farias, Meritxell Galindo Casas, Kathy Delaria, Victor Lui, Kris Poulsen, Janette Sutton, Gary Bolton, Dahui Zhou, Ludivine Moine, Russell Dushin, Thomas-Toan Tran, Shu-Hui Liu, Mathias Rickert, Davide Foletti, Davi

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

IL-2 和 IL-15 之间功能二分法的机制和结构洞察

Aaron M Ring, Jian-Xin Lin, Dan Feng, Suman Mitra, Mathias Rickert, Gregory R Bowman, Vijay S Pande, Peng Li, Ignacio Moraga, Rosanne Spolski, Engin Ozkan, Warren J Leonard, K Christopher Garcia

IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis

IL-7 促进 T(H)1 发育,血清 IL-7 可预测多发性硬化症对干扰素-β 的临床反应

Li-Fen Lee #, Robert Axtell #, Guang Huan Tu, Kathryn Logronio, Jeanette Dilley, Jessica Yu, Mathias Rickert, Bora Han, Winston Evering, Michael G Walker, Jing Shi, Brigit A de Jong, Joep Killestein, Chris H Polman, Lawrence Steinman, John C Lin

Vinyl sulfones as antiparasitic agents and a structural basis for drug design

乙烯基砜作为抗寄生虫剂和药物设计的结构基础

Iain D Kerr, Ji H Lee, Christopher J Farady, Rachael Marion, Mathias Rickert, Mohammed Sajid, Kailash C Pandey, Conor R Caffrey, Jennifer Legac, Elizabeth Hansell, James H McKerrow, Charles S Craik, Philip J Rosenthal, Linda S Brinen