日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Development and validation of a deprescribing tool relevant to older persons in India using modified Delphi consensus technique

利用改进的德尔菲共识技术,开发并验证一种适用于印度老年人的减药工具。

Jhaj, Ratinder; Faruqui, Atiya R; Tripathi, Santanu Kumar; Dhar, Minakshi; Joshi, Rajnish; Shah, Bhushan; Gupta, Snehil; Ul-Haq, Rehan; Javed, Danish; Shukla, Ajay Kumar; Atal, Shubham; Majumdar, Anindo; Cherian, Jerin Jose; Sabu, Sowparnika Treasa; Tiwari, Sandeep; Siddiqui, Bushra; Devi D, Padmini; Kakkar, Ashish Kumar; Selvarajan, Sandhiya; Talukdar, Arunansu; Jain, Vishakha; Khandelwal, Bidita; Kirti, Ravi; Goel, Ashish; Abraham, Vinod Joseph; Kumar, Barun; Singh, Satyajit; Varghese, Kiron; Goyal, Tarun; Kandwal, Pankaj; Santoshi, John Ashutosh; Goyal, Nishant; Sivakumar, Palanimuthu Thangaraju; Varghese, Mathew; Menon, Jaideep; Dhaneria, S P; Pal, Jyotirmoy; Mathur, Arvind; Grover, Sandeep; Jain, Anil

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology

发现新型TLR7激动剂作为全身性药物与抗PD-1抗体联合用于免疫肿瘤学

Poudel, Yam B; He, Liqi; Cox, Matthew; Zhang, Qian; Johnson, Walter L; Cong, Qiang; Cheng, Heng; Chowdari, Naidu S; Tarby, Christine; Donnell, Andrew F; Broekema, Matthais; O'Malley, Daniel P; Zhang, Yong; A M Subbaiah, Murugaiah; Kumar, Boda Vijay; Subramani, Lakshumanan; Wang, Bei; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Sandhu, Bhupindar; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Oderinde, Martins S; Murtaza, Anwar; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology

鉴定和优化小分子吡唑并嘧啶类TLR7激动剂在免疫肿瘤学中的应用

He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F; Zhang, Yong; Tarby, Christine; Gill, Patrice; Subbaiah, Murugaiah A M; Ramar, Thangeswaran; Reddy, Maheswara; Puttapaka, Vijaya; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Murtaza, Anwar; Oderinde, Martins S; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev; Poudel, Yam B

The response to COVID-19 in Timor-Leste: lessons learnt

东帝汶应对新冠疫情的经验教训

Francis, Joshua R; de Araujo, Rui Maria; da Silva Viegas, Odete; Lobo, Sergio; Coelho, Danina; Mathur, Arvind; Bothra, Vinay; Yu, Dongbao; Draper, Anthony D K; Yan, Jennifer; Martins, Nelson

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

BMS-986251 的发现:一种临床上可行、高效且选择性的 RORγt 反向激动剂

Cherney, Robert J; Cornelius, Lyndon A M; Srivastava, Anurag; Weigelt, Carolyn A; Marcoux, David; Duan, James J-W; Shi, Qing; Batt, Douglas G; Liu, Qingjie; Yip, Shiuhang; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John; Khan, Javed; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Mathur, Arvind; Li, Sha; Shuster, David; Khandelwal, Purnima; Borowski, Virna; Xie, Jenny; Obermeier, Mary; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Tino, Joseph A; Macor, John E; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H; Dhar, T G Murali

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

利用旋转稳定的阻转异构体增强效力:发现吡啶并嘧啶二酮-咔唑类BTK抑制剂

Srivastava, Anurag S; Ko, Soo; Watterson, Scott H; Pattoli, Mark A; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T; Vickery, Rodney; Discenza, Lorell N; D'Arienzo, Celia J; Gillooly, Kathleen M; Taylor, Tracy L; Pulicicchio, Claudine; McIntyre, Kim W; Yip, Shiuhang; Li, Peng; Sun, Dawn; Wu, Dauh-Rurng; Dai, Jun; Wang, Chunlei; Zhang, Yingru; Wang, Bei; Pawluczyk, Joseph; Kempson, James; Zhao, Rulin; Hou, Xiaoping; Rampulla, Richard; Mathur, Arvind; Galella, Michael A; Salter-Cid, Luisa; Barrish, Joel C; Carter, Percy H; Fura, Aberra; Burke, James R; Tino, Joseph A

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P(1)) Modulators: Optimization of the PK, PD, and Safety Profiles

芳基醚衍生的鞘氨醇-1-磷酸受体(S1P(1))调节剂:药代动力学、药效学和安全性特征的优化

Xiao, Zili; Yang, Michael G; Dhar, T G Murali; Xiao, Hai-Yun; Gilmore, John L; Marcoux, David; McIntyre, Kim W; Taylor, Tracy L; Shi, Hong; Levesque, Paul C; Marino, Anthony M; Cornelius, Georgia; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D; Sun, Huadong; Xie, Jenny H; Carter, Percy H; Dyckman, Alaric J

Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent

发现强效、选择性强且口服生物利用度高的TGFβR1抑制剂BMS-986260,可作为免疫肿瘤药物

Velaparthi, Upender; Darne, Chetan Padmakar; Warrier, Jayakumar; Liu, Peiying; Rahaman, Hasibur; Augustine-Rauch, Karen; Parrish, Karen; Yang, Zheng; Swanson, Jesse; Brown, Jennifer; Dhar, Gopal; Anandam, Aravind; Holenarsipur, Vinay K; Palanisamy, Kamalavenkatesh; Wautlet, Barri S; Fereshteh, Mark P; Lippy, Jonathan; Tebben, Andrew J; Sheriff, Steven; Ruzanov, Max; Yan, Chunhong; Gupta, Anuradha; Gupta, Arun Kumar; Vetrichelvan, Muthalagu; Mathur, Arvind; Gelman, Marina; Singh, Rajinder; Kinsella, Todd; Murtaza, Anwar; Fargnoli, Joseph; Vite, Gregory; Borzilleri, Robert M