日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models

靶向胱抑素F激活可增强胶质母细胞瘤模型中NK细胞的细胞毒性

Emanuela Senjor ,Anamarija Habič ,Urban Švajger ,Ana Mitrović ,Matic Proj ,Andrej Porčnik ,Borut Prestor ,Miha Jerala ,Matic Bošnjak ,Stanislav Gobec ,Barbara Breznik ,Janko Kos ,Milica Perišić Nanut

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

利用配体的亲和力和特性:发现用于 PROTAC 设计的新型苯甲酰胺型 Cereblon 结合剂

Christian Steinebach, Aleša Bricelj, Arunima Murgai, Izidor Sosič, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Valeriia Sapozhnikova, Annika Schmidt, Maximilian Rudolf Zuleeg, Patricia Lemnitzer, Philipp Mertins, Finn K Hans

Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

发现针对细菌肽聚糖生物合成的 D-Ala:D-Ala 连接酶的片段命中化合物

Matic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec

Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead

具有氯乙酰胺弹头的细菌肽聚糖生物合成酶MurA的共价抑制剂

Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György M Keserű, Stanislav Gobec

New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity

组织蛋白酶 V 的新抑制剂可损害肿瘤细胞增殖和弹性蛋白降解并增加免疫细胞的细胞毒性

Ana Mitrović, Emanuela Senjor, Marko Jukić, Lara Bolčina, Mateja Prunk, Matic Proj, Milica Perišić Nanut, Stanislav Gobec, Janko Kos

Encoding BRAF inhibitor functions in protein degraders

编码 BRAF 抑制剂在蛋白质降解剂中发挥作用

Daniel S J Miller, Sabine A Voell, Izidor Sosič, Matic Proj, Olivia W Rossanese, Gregor Schnakenburg, Michael Gütschow, Ian Collins, Christian Steinebach

Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity

穿心莲内酯衍生物靶向 KEAP1/NRF2 轴并具有强效抗 SARS-CoV-2 活性

Bianca Schulte, Maria König, Beate I Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Izidor Sosič, Hendrik Streeck, Christa E Müller, Michael Gütschow, Christian Steinebach

Targeting the deubiquitinase USP7 for degradation with PROTACs

利用 PROTAC 靶向降解去泛素化酶 USP7

Arunima Murgai, Izidor Sosič, Martina Gobec, Patricia Lemnitzer, Matic Proj, Sophie Wittenburg, Rabea Voget, Michael Gütschow, Jan Krönke, Christian Steinebach

Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads

源自半胱氨酸和苏氨酸靶向弹头的片段大小和双齿(免疫)蛋白酶体抑制剂

Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Péter Ábrányi-Balogh, Dorottya Csányi, György G Ferenczy, Stanislav Gobec, Izidor Sosič, György M Keserű

Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors

弹头修饰补骨脂素作为(免疫)蛋白酶体抑制剂的合成及生化评价

Eva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec, Izidor Sosič