日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

一种用于心脏保护和神经再生的PI3Kα小分子激活剂

Grace Q Gong ,Benoit Bilanges ,Ben Allsop ,Glenn R Masson ,Victoria Roberton ,Trevor Askwith ,Sally Oxenford ,Ralitsa R Madsen ,Sarah E Conduit ,Dom Bellini ,Martina Fitzek ,Matt Collier ,Osman Najam ,Zhenhe He ,Ben Wahab ,Stephen H McLaughlin ,A W Edith Chan ,Isabella Feierberg ,Andrew Madin ,Daniele Morelli ,Amandeep Bhamra ,Vanesa Vinciauskaite ,Karen E Anderson ,Silvia Surinova ,Nikos Pinotsis ,Elena Lopez-Guadamillas ,Matthew Wilcox ,Alice Hooper ,Chandni Patel ,Maria A Whitehead ,Tom D Bunney ,Len R Stephens ,Phillip T Hawkins ,Matilda Katan ,Derek M Yellon ,Sean M Davidson ,David M Smith ,James B Phillips ,Richard Angell ,Roger L Williams ,Bart Vanhaesebroeck

Cells of the human intestinal tract mapped across space and time

人类肠道细胞在空间和时间上的分布图

Rasa Elmentaite ,Natsuhiko Kumasaka ,Kenny Roberts ,Aaron Fleming ,Emma Dann ,Hamish W King ,Vitalii Kleshchevnikov ,Monika Dabrowska ,Sophie Pritchard ,Liam Bolt ,Sara F Vieira ,Lira Mamanova ,Ni Huang ,Francesca Perrone ,Issac Goh Kai'En ,Steven N Lisgo ,Matilda Katan ,Steven Leonard ,Thomas R W Oliver ,C Elizabeth Hook ,Komal Nayak ,Lia S Campos ,Cecilia Domínguez Conde ,Emily Stephenson ,Justin Engelbert ,Rachel A Botting ,Krzysztof Polanski ,Stijn van Dongen ,Minal Patel ,Michael D Morgan ,John C Marioni ,Omer Ali Bayraktar ,Kerstin B Meyer ,Xiaoling He ,Roger A Barker ,Holm H Uhlig ,Krishnaa T Mahbubani ,Kourosh Saeb-Parsy ,Matthias Zilbauer ,Menna R Clatworthy ,Muzlifah Haniffa ,Kylie R James ,Sarah A Teichmann

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

结构洞察和不同病理中的激活突变定义了磷脂酶 C γ 酶失调的机制

Yang Liu, Tom D Bunney, Sakshi Khosa, Kévin Macé, Katharina Beckenbauer, Trevor Askwith, Sarah Maslen, Christopher Stubbs, Taiana M de Oliveira, Kasim Sader, Mark Skehel, Anne-Claude Gavin, Christopher Phillips, Matilda Katan

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations

针对 Src 通路可增强选择性 FGFR 抑制剂对 FGFR3 变异尿路上皮癌的疗效

Nadia Carvalho Lima, Eliza Atkinson, Tom D Bunney, Matilda Katan, Paul H Huang

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

阿尔茨海默病磷脂酶 C-γ-2 (PLCG2) 保护性变体是一种功能性超变体

Lorenza Magno, Christian B Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E Golde, Paul J Whiting

Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa

APLAID 和皮肤松弛症患者出现新的 PLCG2 突变

João Farela Neves, Rainer Doffinger, Gabriela Barcena-Morales, Catarina Martins, Olivier Papapietro, Vincent Plagnol, James Curtis, Marta Martins, Dinakantha Kumararatne, Ana Isabel Cordeiro, Conceição Neves, Luis Miguel Borrego, Matilda Katan, Sergey Nejentsev0

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

FGFR3 的疾病变异揭示了 Hsp90 分子伴侣系统中 Cdc37 识别的分子基础及其他作用

Tom D Bunney ,Alison J Inglis ,Domenico Sanfelice ,Brendan Farrell ,Christopher J Kerr ,Gary S Thompson ,Glenn R Masson ,Nethaji Thiyagarajan ,Dmitri I Svergun ,Roger L Williams ,Alexander L Breeze ,Matilda Katan

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach

通过化学蛋白质组学方法对亨廷顿蛋白相关蛋白 E (HYPE) 介导的 AMPylation 进行整体分析

Malgorzata Broncel, Remigiusz A Serwa, Tom D Bunney, Matilda Katan, Edward W Tate

A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency

编码磷脂酶 Cγ2 的 PLCG2 的超态错义突变导致一种具有免疫缺陷的显性遗传自身炎症性疾病

Qing Zhou, Geun-Shik Lee, Jillian Brady, Shrimati Datta, Matilda Katan, Afzal Sheikh, Marta S Martins, Tom D Bunney, Brian H Santich, Susan Moir, Douglas B Kuhns, Debra A Long Priel, Amanda Ombrello, Deborah Stone, Michael J Ombrello, Javed Khan, Joshua D Milner, Daniel L Kastner, Ivona Aksentijevic

Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF

PLCε 活性促进成纤维细胞向 PDGF 趋化

Marta Martins, Sean Warren, Christopher Kimberley, Anca Margineanu, Pascal Peschard, Afshan McCarthy, Maggie Yeo, Christopher J Marshall, Christopher Dunsby, Paul M W French, Matilda Katan