日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.

家族性高胆固醇血症基因 LDLR 编码变异的功能图谱。

Tabet Daniel R, Coté Atina G, Lancaster Megan C, Weile Jochen, Rayhan Ashyad, Fotiadou Iosifina, Kishore Nishka, Li Roujia, Kuang Da, Knapp Jennifer J, Carrero Carmela S, Taverniti Olivia, Axakova Anna, Castelli Jack M P, Islam Mohammad M, Sowlati-Hashjin Shahin, Gandhi Aanshi, Maaieh Ranim, Garton Michael, Matreyek Kenneth, Fowler Douglas M, Bourbon Mafalda, Pfisterer Simon G, Glazer Andrew M, Kroncke Brett M, Parikh Victoria N, Ashley Euan A, Knowles Joshua W, Claussnitzer Melina, Cirulli Elizabeth T, Hegele Robert A, Roden Dan M, MacRae Calum A, Roth Frederick P

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

对人胰岛素受体胞外结构域进行深度突变扫描,以指导胰岛素抵抗的精准治疗。

Vahid Aslanzadeh ,Gemma V Brierley ,Rupa Kumar ,Hasan Çubuk ,Corinne Vigouroux ,Kenneth A Matreyek ,Grzegorz Kudla ,Robert K Semple

The quantitative impact of 3'UTRs on gene expression

3'UTR对基因表达的定量影响

West, Jessica D; Smith, Hannah J; Vu, Luyen Tien; Fogarty, Elizabeth A; Matreyek, Kenneth A; Fowler, Douglas M; Grimson, Andrew

BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies.

BOGO:用于发现合理癌症联合疗法的蛋白质组范围基因过表达平台

Jo Kyeong Beom, Alruwaili Mohammed M, Kim Da-Eun, Koh Yongjun, Kim Hyeyeon, You Kwontae, Kim Ji-Sun, Sane Saba, Guo Yanqi, Wright Jacob P, Lim Hyobin Julianne, Naranjo Maricris N, Coté Atina G, Roth Frederick P, Hill David E, Choi Jung-Hyun, Lee Hunsang, Matreyek Kenneth A, Farh Kyle K-H, Park Jong-Eun, Kim Hyunkyung, Bakin Andrei V, Kim Dae-Kyum

Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike

SARS-CoV-2刺突蛋白融合机制核心中存在抗原漂移的证据

Tan, Timothy J C; Verma, Abhishek K; Odle, Abby; Lei, Ruipeng; Meyerholz, David K; Matreyek, Kenneth A; Perlman, Stanley; Wong, Lok-Yin Roy; Wu, Nicholas C

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

利用高通量技术鉴定SARS-CoV-2刺突蛋白中融合前稳定突变

Timothy J C Tan ,Zongjun Mou ,Ruipeng Lei ,Wenhao O Ouyang ,Meng Yuan ,Ge Song ,Raiees Andrabi ,Ian A Wilson ,Collin Kieffer ,Xinghong Dai ,Kenneth A Matreyek ,Nicholas C Wu

Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators

光遗传学微孔阵列筛选系统:一种用于基因编码荧光指示剂的高通量工程平台

Michael Rappleye, Sarah J Wait, Justin Daho Lee, Jamison C Siebart, Lily Torp, Netta Smith, Jeanot Muster, Kenneth A Matreyek, Douglas M Fowler, Andre Berndt

Abstract 1657: Design and Evaluation of Buforin II Variants with Enhanced DNA Binding and Antimicrobial Activity

摘要 1657:具有增强的 DNA 结合能力和抗菌活性的 Buforin II 变体的设计与评价

Duxbury, Mark S; Ito, Hiromichi; Ashley, Stanley W; Whang, Edward E; Mohideen, F Ifthiha; Raeisimakiani, Parisa; Mahal, Lara; Powell, Rebecca; Hayashi, Takuma; Hayashi, Takuma; Yaegashi, Nobuo; Konishi, Ikuo; Shukla, Nidhi; Kamath, Nisha; Roelle, Sarah; Bruchez, Anna; Matreyek, Kenneth; Tsyrlov, Ilya; Shur, Irina; Shah, Sahana; Stuwe, Hannah; Hughes, Kaitlyn; Reardon, Patrick; Yu, Zhen; Barbar, Elisar; Hernandez, Dulce; Harne, Rakhi; Williams, Brittany; Baldwin, Susan; Coler, Rhea; Wang, Yan; Li, Ling; Willard, Belinda; Maytin, Edward; Hascall, Vincent; Guseman, Alex; Rennick, Linda; Nambulli, Sham; Bhinderwhala, Fatema; Martinez, David; Baric, Ralph; Duprex, Paul; Gronenborn, Angela; Philipp, Manfred; Boldyrev, Mary; Roman, David; Mcdevitt, Matthew; Gonzalez, Janet; Clement, Cristina; Kim, Gabriela; Li, Qiao; Jing, Lisha; Radhakrishnan, Mala; Elmore, Donald

Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome K(ATP) Channel Mutations in Intact Cells

快速表征坎图综合征K(ATP)通道突变在完整细胞中的功能和药理学后果

Gao, Jian; McClenaghan, Conor; Matreyek, Kenneth A; Grange, Dorothy K; Nichols, Colin G

Mammalian Genomic Manipulation with Orthogonal Bxb1 DNA Recombinase Sites for the Functional Characterization of Protein Variants

利用正交Bxb1 DNA重组酶位点进行哺乳动物基因组操作,以进行蛋白质变体的功能表征

Sarah M Roelle,Nisha D Kamath,Kenneth A Matreyek