GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease.
在亚历山大病的鼠模型中,GFAP 突变和星形胶质细胞功能障碍导致神经退行性改变,表现为突触可塑性受损和认知缺陷
期刊:eNeuro
影响因子:2.7
doi:10.1523/ENEURO.0504-24.2025
Berman Robert F, Matson Matthew R, Bachman Angelica M, Lin Ni-Hsuan, Coyne Sierra, Frelka Alyssa, Pearce Robert A, Messing Albee, Hagemann Tracy L