日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protein CREATE enables closed-loop design of de novo synthetic protein binders

Protein CREATE 可实现从头合成蛋白质结合剂的闭环设计

Alec Lourenço, Arjuna Subramanian, Ryan Spencer, Michael Anaya, Jiapei Miao, William Fu, Eric Chow, Matt Thomson

Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and disease

空间转录组学定义肾脏再生和疾病中的损伤特异性微环境和细胞相互作用

Michal Polonsky #, Louisa M S Gerhardt #, Jina Yun, Kari Koppitch, Katsuya Lex Colón, Henry Amrhein, Barbara Wold, Shiwei Zheng, Guo-Cheng Yuan, Matt Thomson, Long Cai, Andrew P McMahon

Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs

通过合成 Notch 受体设计可编程材料到细胞的通路,以在空间上控制多细胞结构的分化

Mher Garibyan #, Tyler Hoffman #, Thijs Makaske, Stephanie K Do, Yifan Wu, Brian A Williams, Alexander R March, Nathan Cho, Nicolas Pedroncelli, Ricardo Espinosa Lima, Jennifer Soto, Brooke Jackson, Jeffrey W Santoso, Ali Khademhosseini, Matt Thomson, Song Li, Megan L McCain, Leonardo Morsut

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

共生菌促进I型干扰素信号传导以维持小鼠的免疫耐受性

Adriana Vasquez Ayala, Chia-Yun Hsu, Renee E Oles, Kazuhiko Matsuo, Luke R Loomis, Ekaterina Buzun, Marvic Carrillo Terrazas, Romana R Gerner, Hsueh-Han Lu, Sohee Kim, Ziyue Zhang, Jong Hwee Park, Paul Rivaud, Matt Thomson, Li-Fan Lu, Booki Min, Hiutung Chu

D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response

D-SPIN 从多路复用 scRNA-seq 数据构建基因调控网络模型,揭示细胞扰动响应的组织原理

Jialong Jiang, Sisi Chen, Tiffany Tsou, Christopher S McGinnis, Tahmineh Khazaei, Qin Zhu, Jong H Park, Inna-Marie Strazhnik, Jost Vielmetter, Yingying Gong, John Hanna, Eric D Chow, David A Sivak, Zev J Gartner, Matt Thomson

Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

运动过程和速度决定了微管马达组件的结构和动力学

Rachel A Banks, Vahe Galstyan, Heun Jin Lee, Soichi Hirokawa, Athena Ierokomos, Tyler D Ross, Zev Bryant, Matt Thomson, Rob Phillips

Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension

干细胞衍生的合成胚胎利用钙粘蛋白代码和皮质张力进行自组装

Min Bao, Jake Cornwall-Scoones, Estefania Sanchez-Vasquez, Andy L Cox, Dong-Yuan Chen, Joachim De Jonghe, Shahriar Shadkhoo, Florian Hollfelder, Matt Thomson, David M Glover, Magdalena Zernicka-Goetz

Deep Parallel Characterization of AAV Tropism and AAV-Mediated Transcriptional Changes via Single-Cell RNA Sequencing

通过单细胞 RNA 测序深度并行表征 AAV 趋向性和 AAV 介导的转录变化

David Brown, Michael Altermatt, Tatyana Dobreva, Sisi Chen, Alexander Wang, Matt Thomson, Viviana Gradinaru

Single cell profiling of capillary blood enables out of clinic human immunity studies

毛细血管血的单细胞分析使临床外人体免疫研究成为可能

Tatyana Dobreva, David Brown, Jong Hwee Park, Matt Thomson

Dissecting heterogeneous cell populations across drug and disease conditions with PopAlign

使用 PopAlign 解剖不同药物和疾病条件下的异质细胞群

Sisi Chen, Paul Rivaud, Jong H Park, Tiffany Tsou, Emeric Charles, John R Haliburton, Flavia Pichiorri, Matt Thomson