日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Myeloperoxidase: one enzyme, two jobs

髓过氧化物酶:一种酶,两种功能

Marchese, Sara; Mattevi, Andrea

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

PRMT5 和 LSD1 抑制剂在急性髓系白血病中存在协同作用。

Param Nesteene Joy, Arceci Elisa, Fiorentino Francesco, Pignata Luca, Torre Denis, Gutiérrez-Trejo Nayeli, Fong Jia Yi, Goy Pierre-Alexis, Han Brenda Y, Lambona Chiara, Di Bello Elisabetta, Castiello Carola, Barone Marco, Schwarz Megan, Arrowsmith Cheryl, Ito Koichi, Scherle Peggy, Wee Dave Keng Boon, Ndoye Steven, Tabaglio Tommaso, Jeyasekharan Anand D, Lakshmanan Manikandan, Cirilli Roberto, Habisch Hansjörg, Madl Tobias, Mattevi Andrea, Valente Sergio, Mai Antonello, Guccione Ernesto

The glycine-arginine-rich motif of 53BP1 modulates RNA interactions necessary for its liquid-liquid phase separation during DNA Damage Response

53BP1 中富含甘氨酸-精氨酸的基序调节 RNA 相互作用,这对于其在 DNA 损伤反应过程中发生液-液相分离至关重要。

Terraneo, Federica; Ceccon, Marta; Sapkota, Oscar; Zheng, Tongyin; Brizioli, Matteo; Dello Stritto, Angela; Cummings, Samara; Codispoti, Simone; Ossolengo, Giuseppe; Orsenigo, Fabrizio; Magni, Serena; Gottinger, Andrea; Mattevi, Andrea; Fuxreiter, Monika; Fawzi, Nicolas L; Lottersberger, Francisca; Giavazzi, Fabio; d'Adda di Fagagna, Fabrizio

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

AI增强型自适应虚拟筛选平台可探索690亿个分子,并发现结构验证的FSP1抑制剂

Cecchini, Domiziana; Nigam, AkshatKumar; Tang, Ming; Reis, Joana; Koop, Matt; Gottinger, Andrea; Nicoll, Callum Robert; Wang, Yao; Jayaraj, Abhilash; Çınaroğlu, Süleyman Selim; Törner, Ricarda; Malets, Yehor; Gehev, Minko; Das, Krishna M Padmanabha; Churion, Kelly; Kim, Jongwan; Thomas, Nidhin; Li, Yong; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Secker, Christopher; Haddadnia, Mohammad; Hasson, Alexander; Li, Minkai; Kumar, Abhishek; Levin-Konigsberg, Roni; Choi, Eun-Bee; Shapiro, Geoffrey I; Cox, Huel; Sebastian, Luke; Braithwaite, Chelsea; Bashyal, Puspalata; Radchenko, Dmytro S; Kumar, Aditya; Yang, Lei; Aquilanti, Pierre-Yves; Gabb, Henry; Alhossary, Amr; Wagner, Gerhard; Aspuru-Guzik, Alán; Moroz, Yurii S; Kalodimos, Charalampos G; Fackeldey, Konstantin; Schuetz, John D; Mattevi, Andrea; Arthanari, Haribabu; Gorgulla, Christoph

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.

共价加合物 Grob 断裂是 LSD1 去甲基酶特异性抑制剂作用机制和耐药性的基础

Waterbury Amanda L, Caroli Jonatan, Zhang Olivia, Tuttle Paloma R, Liu Chao, Li Jiaming, Park Ji Sung, Hoenig Samuel M, Barone Marco, Furui Airi, Mattevi Andrea, Liau Brian B

Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1.

通过改造赖氨酸去甲基酶 LSD1 来解耦组蛋白修饰串扰

Lee Kwangwoon, Barone Marco, Waterbury Amanda L, Jiang Hanjie, Nam Eunju, DuBois-Coyne Sarah E, Whedon Samuel D, Wang Zhipeng A, Caroli Jonatan, Neal Katherine, Ibeabuchi Brian, Dhoondia Zuzer, Kuroda Mitzi I, Liau Brian B, Beck Samuel, Mattevi Andrea, Cole Philip A

Dehydrogenase versus oxidase function: the interplay between substrate binding and flavin microenvironment

脱氢酶与氧化酶的功能:底物结合与黄素微环境的相互作用

Guerriere, Teresa Benedetta; Vancheri, Alessandro; Ricotti, Ilaria; Serapian, Stefano A; Eggerichs, Daniel; Tischler, Dirk; Colombo, Giorgio; Mascotti, Maria L; Fraaije, Marco W; Mattevi, Andrea

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

基于反式环丙胺的LSD1抑制剂可有效降低曼氏血吸虫的存活率

Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Ganesan, A; Fioravanti, Rossella; Zwergel, Clemens; Lambona, Chiara; Valente, Sergio; Fianco, Giulia; Iuzzolino, Angela; Trisciuoglio, Daniela; Caroli, Jonatan; Mattevi, Andrea; Häberli, Cécile; Keiser, Jennifer; Rotili, Dante; Mai, Antonello

Structural and Mechanistic Characterization of the Flavin-Dependent Monooxygenase and Oxidase Involved in Sorbicillinoid Biosynthesis

参与山梨醇类化合物生物合成的黄素依赖性单加氧酶和氧化酶的结构和机制表征

Tjallinks, Gwen; Angeleri, Nicolò; Nguyen, Quoc-Thai; Mannucci, Barbara; Arentshorst, Mark; Visser, Jaap; Ram, Arthur F J; Fraaije, Marco W; Mattevi, Andrea

Evolution, structure, and drug-metabolizing activity of mammalian prenylcysteine oxidases

哺乳动物异戊二烯基半胱氨酸氧化酶的进化、结构和药物代谢活性

Barone, Marco; Pizzorni, Letizia; Fraaije, Marco W; Mascotti, Maria L; Mattevi, Andrea