Anti-tumor NAMPT inhibitor, KPT-9274, mediates gender-dependent murine anemia and nephrotoxicity by regulating SIRT3-mediated SOD deacetylation
抗肿瘤 NAMPT 抑制剂 KPT-9274 通过调节 SIRT3 介导的 SOD 去乙酰化作用，导致小鼠出现性别依赖性贫血和肾毒性。
期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-021-01107-0
Mitchell, Shaneice; Zhang, Pu; Cannon, Matthew; Beaver, Larry; Lehman, Amy; Harrington, Bonnie; Sampath, Deepa; Byrd, John C; Lapalombella, Rosa
肿瘤
表观遗传
肿瘤免疫
代谢
乙酰化
NAMPT
毒理研究
贫血
