日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis

大规模外显子组分析揭示了肌萎缩侧索硬化症中新的罕见变异贡献

Hop, Paul J; Kooyman, Maarten; Kenna, Brendan J; Zwamborn, Ramona A J; van Eijk, Kristel R; Wang, Yan; van Dijk, Charlotte H; Bekema, Erwin; van Rheenen, Wouter; Beele, Paul; van Vugt, Joke J F A; Khleifat, Ahmad Al; Iacoangeli, Alfredo; Cooper-Knock, Johnathan; Smith, Bradley N; Topp, Simon; van der Kooi, Anneke J; Fominykh, Vera; Drory, Vivian; Lerner, Yossef; Shovman, Yehuda; Rowe, Dominic B; Williams, Kelly L; McLaughlin, Russell L; Hurt, Jessica; Huang, Yunfeng; Chen, Chia-Yen; Tsai, Ellen; Runz, Heiko; Aronica, Eleonora; Groen, Ewout J N; van Es, Michael A; Pasterkamp, R Jeroen; Farhan, Sali M K; Garton, Fleur C; McRae, Allan F; McCombe, Pamela A; Henderson, Robert D; Fan, Dongsheng; Šlachtová, Lenka; Høyer, Helle; Nishimura, Agnes L; Cauchi, Ruben J; Brylev, Lev; Rogelj, Boris; Koritnik, Blaž; Zidar, Janez; Salas, Teresa; Mora Pardina, Jesus S; Gotkine, Marc; Povedano, Monica; Corcia, Philippe; Vourc'h, Patrick; Couratier, Philippe; Weber, Markus; Kiernan, Matthew C; Pamphlett, Roger; Blair, Ian P; de Carvalho, Mamede; Başak, Nazli A; Ingre, Caroline; Andersen, Peter M; Zinman, Lorne; Rogaeva, Ekaterina; MacKenzie, Ian R; Dupre, Nicolas; Rouleau, Guy A; Traynor, Bryan J; Ticozzi, Nicola; Chiò, Adriano; Silani, Vincenzo; Hardiman, Orla; Phatnani, Hemali; Harms, Matthew B; Dalgard, Clifton L; Glass, Jonathan D; Landers, John E; Van Damme, Philip; Morrison, Karen E; Shaw, Pamela J; Shaw, Chris E; Al-Chalabi, Ammar; van den Berg, Leonard H; Kenna, Kevin P; Veldink, Jan H

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy

对散发性ALS患者诱导多能干细胞衍生的运动神经元进行大规模药物筛选,发现了一种潜在的联合疗法

Bye, Christopher R; Qian, Elizabeth; Lim, Katherine; Daniszewski, Maciej; Garton, Fleur C; Trần-Lê, Bảo C; Liang, Helena H; Lin, Tian; Lock, John G; Crombie, Duncan E; Morgan, Steven; Hu, Yi; Barton, Samantha K; Palmer, Lucy M; Djouma, Elvan; Kodikara, Saritha; Lê Cao, Kim-Anh; Dharmadasa, Thanuja; Henders, Anjali K; Ziser, Laura A; Kiernan, Matthew C; Talbot, Kevin; Needham, Merrilee; Fletcher, Susan; Talman, Paul; Mathers, Susan; Wray, Naomi R; Hewitt, Alex W; Pebay, Alice; Turner, Bradley J

Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19

经验性使用阿奇霉素会改变新冠肺炎患者的上呼吸道微生物群和耐药组,但并未产生抗炎作用。

Glascock, Abigail; Maguire, Cole; Phan, Hoang Van; Lydon, Emily C; Schaenman, Joanna; Calfee, Carolyn S; Melamed, Esther; Greenland, John; Corry, David B; Kheradmand, Farrah; Baden, Lindsey R; Sekaly, Rafick; McComsey, Grace A; Haddad, Elias K; Cairns, Charles B; Geng, Linda N; Pulendran, Bali; Fernandez-Sesma, Ana; Simon, Viviana; Metcalf, Jordan P; Agudelo Higuita, Nelson I; Messer, William B; Davis, Mark M; Nadeau, Kari C; Kraft, Monica; Bime, Christian; Erle, David J; Atkinson, Mark A; Brakenridge, Scott C; Ehrlich, Lauren I R; Montgomery, Ruth R; Shaw, Albert C; Hough, Catherine L; Hafler, David A; Augustine, Alison D; Becker, Patrice M; Peters, Bjoern; Ozonoff, Al; Hoch, Annmarie; Kim-Schulze, Seunghee; Krammer, Florian; Bosinger, Steven; Eckalbar, Walter; Altman, Matthew C; Wilson, Michael; Guan, Leying; Maecker, Holden; Steen, Hanno; Diray-Arce, Joann; Rouphael, Nadine; Kleinstein, Steven H; Jayavelu, Naresh Doni; Reed, Elaine F; Levy, Ofer; Chu, Victoria T; Langelier, Charles R

Photocatalytic Cross-Coupling of Phenols and Heteroaryl Halides With Machine Learning-Guided Reaction Prediction

基于机器学习指导的反应预测的酚类与杂芳基卤化物光催化交叉偶联反应

Carson, Matthew C; Wu, Alice; Duggal, Kalyana B; Rotella, Madeline E; Kozlowski, Marisa C

Mithramycin alters EWS::FLI1 DNA binding and RNA polymerase II processivity to inhibit nascent transcription

米索霉素通过改变 EWS::FLI1 与 DNA 的结合以及 RNA 聚合酶 II 的加工能力来抑制新生转录。

Kaufman, Rebecca; Flores, Guillermo; Boguslawski, Elissa A; Kinn-Gurzo, Seneca; Chassé, Maggie; Beddows, Ian; Adams, Marie; Stout, Matthew C; Gaetano, Lauren; Lopez, Raphael; Veluvolu, Sridhar; Fuller, Andrew; Kitchen-Goosen, Susan M; Tolstyka, Zachary P; Gedminas, Jenna M; Grohar, Patrick J

Delivery of peptide coacervates to form stable interaction hubs in cells.

将肽凝聚体递送至细胞内,形成稳定的相互作用中心。

Tu Wangjie, Theisen Rachel Q, Jin Pengfei, Chenoweth David M, Patel Amish J, Good Matthew C

STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.

STING激活通过炎症细胞死亡途径诱导脑膜瘤细胞毒性和免疫反应。

Youngblood Mark W, Tripathi Shashwat, Najem Hinda, Congivaram Harrshavasan, Gomez Mateo, Sears Thomas K, Hurley Lisa, Billingham Leah K, Silvers Caylee, Wang Wenxia, Tiek Deanna, Sadagopan Nishanth, Chaliparambil Rahul, Pu Qianyi, Wai Ching Man, Choudhury Abrar, Steffens Alicia, McCortney Kathleen, Vazquez Cervantes Gustavo Ignacio, Oyon Daniel, Fernandez Luis, Selner Ashley, Fares Jawad, Hagan Matthew, Joy Trybula S, Yeung Jacky, Peyre Matthieu, Kalamarides Michel, Zhang Peng, Stegh Alexander H, Ashley David M, Horbinski Craig M, Ahrendsen Jared T, Jamshidi Pouya, Brat Daniel J, Lukas Rimas V, Stupp Roger, Lesniak Maciej S, Sonabend Adam M, Dunn Gavin P, Chandler James P, Tate Matthew C, Magill Stephen T, Miska Jason, Curran Michael A, Raleigh David R, Heimberger Amy B

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle.

USP30 的激活通过调节 S-腺苷甲硫氨酸循环破坏内皮细胞功能并加重急性肺损伤。

Baoyinna Baoyinna, He Jinshan, Miao Jiaxing, Shaheen Nargis, Xia Boyu, Wang Cankun, Ma Qin, Bernier Matthew C, Whitson Bryan A, Sun Nuo, Zhao Jing, Zhao Yutong

Functional interrogation of contextually correct MYH7 variants using CRaTER-flox gene editing and contractility profiling

利用 CRaTER-flox 基因编辑和收缩性分析对上下文正确的 MYH7 变体进行功能性研究

Loiben, Alexander M; Chien, Wei-Ming; McKinstry, Ashley; Ahmed, Dania; Childers, Matthew C; Regnier, Michael; Murry, Charles E; Yang, Kai-Chun

Allogeneic gene therapy with BMP-2-transduced mesenchymal stem cells combined with immunosuppression enhances bone healing

采用BMP-2转导的间充质干细胞进行同种异体基因治疗,并结合免疫抑制疗法,可促进骨愈合。

Ball, Jacob R; Gallo, Matthew C; Wier, Julian; Hernandez, Fergui; Shelby, Tara; Elias, Aura; Reynolds, Julius; Sugiyama, Osamu; Tang, Amy; Park, Sang-Hyun; Lieberman, Jay R