Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy
6-氯-5-[4-(1-羟基环丁基)苯基]-1H-吲哚-3-羧酸 (PF-06409577) 的发现和临床前表征，它是腺苷酸活化蛋白激酶 (AMPK) 的直接激活剂，可用于治疗糖尿病肾病
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6b00866
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Christopher T Salatto, Jessica Ward, Jane M Withka, Samit K Bhattacharya, Markus Boehm, Kris A Borzilleri, Janice A Brown, Matthew Calabrese, Nicole L Caspers, Emily Cokorinos, Edward L Conn, Matthew S Dowling, Da
