日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

使用 Pirin 蛋白降解探针 (CCT367766) 展示细胞内靶标参与

Nicola E A Chessum, Swee Y Sharp, John J Caldwell, A Elisa Pasqua, Birgit Wilding, Giampiero Colombano, Ian Collins, Bugra Ozer, Meirion Richards, Martin Rowlands, Mark Stubbs, Rosemary Burke, P Craig McAndrew, Paul A Clarke, Paul Workman, Matthew D Cheeseman, Keith Jones

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70

利用蛋白质构象变化优化腺苷衍生的 HSP70 抑制剂

Matthew D Cheeseman, Isaac M Westwood, Olivier Barbeau, Martin Rowlands, Sarah Dobson, Alan M Jones, Fiona Jeganathan, Rosemary Burke, Nadia Kadi, Paul Workman, Ian Collins, Rob L M van Montfort, Keith Jones

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

基于片段的方法应用于高度灵活的目标:对 HSP70 异构体抑制的见解和挑战

Alan M Jones, Isaac M Westwood, James D Osborne, Thomas P Matthews, Matthew D Cheeseman, Martin G Rowlands, Fiona Jeganathan, Rosemary Burke, Diane Lee, Nadia Kadi, Manjuan Liu, Meirion Richards, Craig McAndrew, Norhakim Yahya, Sarah E Dobson, Keith Jones, Paul Workman, Ian Collins, Rob L M van Mont

Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

研究 Apoptozole 作为 HSP70 抑制的化学探针

Lindsay E Evans, Matthew D Cheeseman, Norhakim Yahya, Keith Jones