日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

1,5-二取代 α-氨基四唑衍生物的设计、合成和生物学评价,作为非共价炎症小体-caspase-1 复合物抑制剂,具有治疗免疫和炎症疾病的潜在应用价值

Fausta Ulgheri, Pietro Spanu, Francesco Deligia, Giovanni Loriga, Maria Pia Fuggetta, Iris de Haan, Ajay Chandgudge, Matthew Groves, Alexander Domling

A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wt osteosarcoma cells

一种基于氟化吲哚的MDM2拮抗剂选择性抑制p53wt骨肉瘤细胞的生长

Lukasz Skalniak ,Aleksandra Twarda-Clapa ,Constantinos G Neochoritis ,Ewa Surmiak ,Monika Machula ,Aneta Wisniewska ,Beata Labuzek ,Ameena M Ali ,Sylwia Krzanik ,Grzegorz Dubin ,Matthew Groves ,Alexander Dömling ,Tad A Holak

Canonical signal recognition particle components can be bypassed for posttranslational protein targeting in chloroplasts

可以绕过典型的信号识别颗粒成分,实现叶绿体中的翻译后蛋白质靶向

Tzvetelina Tzvetkova-Chevolleau, Claire Hutin, Laurent D Noël, Robyn Goforth, Jean-Pierre Carde, Stephano Caffarri, Irmgard Sinning, Matthew Groves, Jean-Marie Teulon, Neil E Hoffman, Ralph Henry, Michel Havaux, Laurent Nussaume