日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ultrafast structural changes direct the first molecular events of vision

超快结构变化指导视觉的第一个分子事件

Thomas Gruhl, Tobias Weinert #, Matthew J Rodrigues #, Christopher J Milne, Giorgia Ortolani, Karol Nass, Eriko Nango, Saumik Sen, Philip J M Johnson, Claudio Cirelli, Antonia Furrer, Sandra Mous, Petr Skopintsev, Daniel James, Florian Dworkowski, Petra Båth, Demet Kekilli, Dmitry Ozerov, Rie Tanaka

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

发现细胞活性 BCL6 抑制剂:有效结合生化 HTS 与多种生物物理技术、X 射线晶体学和基于细胞的分析

Olivier A Pierrat, Manjuan Liu, Gavin W Collie, Kartika Shetty, Matthew J Rodrigues, Yann-Vaï Le Bihan, Emma A Gunnell, P Craig McAndrew, Mark Stubbs, Martin G Rowlands, Norhakim Yahya, Erald Shehu, Rachel Talbot, Lisa Pickard, Benjamin R Bellenie, Kwai-Ming J Cheung, Ludovic Drouin, Paolo Innocenti

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

通过发现和优化苯并咪唑酮 BCL6 降解剂实现体内靶标耗竭

Benjamin R Bellenie, Kwai-Ming J Cheung, Ana Varela, Olivier A Pierrat, Gavin W Collie, Gary M Box, Michael D Bright, Sharon Gowan, Angela Hayes, Matthew J Rodrigues, Kartika N Shetty, Michael Carter, Owen A Davis, Alan T Henley, Paolo Innocenti, Louise D Johnson, Manjuan Liu, Selby de Klerk, Yann-V