日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation

ATG16L1 的 WD40 结构域缺失会加重急性胰腺炎,消除 LAP 样非经典自噬并减缓胰蛋白酶降解

Michael Chvanov, Svetlana Voronina, Matthew Jefferson, Ulrike Mayer, Robert Sutton, David N Criddle, Thomas Wileman, Alexei V Tepikin

The WD Domain of Atg16l1 Crucial for LC3-Associated Phagocytosis Is Not Required for Preserving Skin Barrier Function in Mice

Atg16l1 的 WD 结构域对 LC3 相关吞噬作用至关重要,但对维持小鼠的皮肤屏障功能并非必需

Shannon Conway, Matthew Jefferson, Derek T Warren, Thomas Wileman, Christopher J Morris

LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation

骨髓巨噬细胞中的 LC3 相关吞噬作用通过激活 STING 抑制急性髓系白血病进展

Jamie A Moore, Jayna J Mistry, Charlotte Hellmich, Rebecca H Horton, Edyta E Wojtowicz, Aisha Jibril, Matthew Jefferson, Thomas Wileman, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus

ATG16L1在上皮细胞中的非经典自噬功能限制了甲型流感病毒的致命感染

Yingxue Wang ,Parul Sharma ,Matthew Jefferson ,Weijiao Zhang ,Ben Bone ,Anja Kipar ,David Bitto ,Janine L Coombes ,Timothy Pearson ,Angela Man ,Alex Zhekova ,Yongping Bao ,Ralph A Tripp ,Simon R Carding ,Yohei Yamauchi ,Ulrike Mayer ,Penny P Powell ,James P Stewart ,Thomas Wileman

Regulators, Pivotal Clinical Trials, and Drug Regulation in the Age of COVID-19

新冠疫情时代下的监管机构、关键临床试验和药物监管

Lexchin, Joel; Graham, Janice; Herder, Matthew; Jefferson, Tom; Lemmens, Trudo

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis

ATG16L1 的 ATG5 结合结构域和卷曲螺旋结构域独立于 LC3 相关吞噬作用所需的 WD 结构域,维持小鼠的自噬和组织稳态

Shashank Rai, Maryam Arasteh, Matthew Jefferson, Timothy Pearson, Yingxue Wang, Weijiao Zhang, Bertalan Bicsak, Devina Divekar, Penny P Powell, Ronald Naumann, Naiara Beraza, Simon R Carding, Oliver Florey, Ulrike Mayer, Thomas Wileman

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

肠道类器官潘氏细胞蛋白质组学和转录组学数据的综合分析揭示了依赖于自噬的功能过程

Emily J Jones, Zoe J Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D Armstrong, Lindsay J Hall, Alastair J M Watson, Simon R Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P Powell, Isabelle Haut

The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2α Phosphorylation and Stress Granule Formation

自噬蛋白 ATG16L1 是辛德比斯病毒诱导的 eIF2α 磷酸化和应激颗粒形成所必需的

Matthew Jefferson, Benjamin Bone, Jasmine L Buck, Penny P Powell

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex

与瘟病毒 N 端蛋白酶 Npro 相互作用的宿主因子是核糖核蛋白复合物的组成部分

Matthew Jefferson, Andras Donaszi-Ivanov, Sean Pollen, Tamas Dalmay, Gerhard Saalbach, Penny P Powell

The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.)

瘟病毒N末端蛋白酶Npro重新分布到线粒体和过氧化物酶体,提示Npro对IRF3有新的调控位点。

Matthew Jefferson, Matthew Whelband, Irina Mohorianu, Penny P Powell