日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia

靶向 LMO2 诱导的自分泌 FLT3 信号以克服早期 T 细胞前体急性淋巴细胞白血病的化学耐药性

Cedric S Tremblay, Jesslyn Saw, Feng Yan, Jacqueline A Boyle, Ovini Amarasinghe, Shokoufeh Abdollahi, Anh N Q Vo, Benjamin J Shields, Chelsea Mayoh, Hannah McCalmont, Kathryn Evans, Anna Steiner, Kevin Parsons, Matthew P McCormack, David R Powell, Nicholas C Wong, Stephen M Jane, Richard B Lock, Dav

Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Hhex 直接抑制 BIM 依赖性细胞凋亡,促进 NK 细胞的发育和维持

Wilford Goh, Sebastian Scheer, Jacob T Jackson, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Iona S Schuster, Christopher E Andoniou, Jai Rautela, Mariapia A Degli-Esposti, Melissa J Davis, Matthew P McCormack, Stephen L Nutt, Nicholas D Huntington

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Hhex 诱导早幼粒细胞自我更新并与生长因子独立性协同作用导致小鼠发生髓系白血病

Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

限制胸腺前体供应会增加小鼠 X 连锁严重联合免疫缺陷症中淋巴系统恶性肿瘤的风险

Samantha L Ginn, Claus V Hallwirth, Sophia H Y Liao, Erdahl T Teber, Jonathan W Arthur, Jianmin Wu, Hong Ching Lee, Szun S Tay, Min Hu, Roger R Reddel, Matthew P McCormack, Adrian J Thrasher, Marina Cavazzana, Stephen I Alexander, Ian E Alexander0

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Hhex 通过抑制 Cdkn2a 来调节造血干细胞自我更新和应激造血

Jacob T Jackson, Benjamin J Shields, Wei Shi, Ladina Di Rago, Donald Metcalf, Nicos A Nicola, Matthew P McCormack

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

急性髓系白血病需要Hhex来启动PRC2介导的Cdkn2a表观遗传抑制。

Benjamin J Shields,Jacob T Jackson,Donald Metcalf,Wei Shi,Qiutong Huang,Alexandra L Garnham,Stefan P Glaser,Dominik Beck,John E Pimanda,Clifford W Bogue,Gordon K Smyth,Warren S Alexander,Matthew P McCormack

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

通过 ENU 诱导的小鼠突变体揭示红系锚蛋白-1 的新作用

Gerhard Rank, Rosemary Sutton, Vikki Marshall, Rachel J Lundie, Jacinta Caddy, Tony Romeo, Kate Fernandez, Matthew P McCormack, Brian M Cooke, Simon J Foote, Brendan S Crabb, David J Curtis, Douglas J Hilton, Benjamin T Kile, Stephen M Jane

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

转录因子Scl在应激性血小板生成过程中血小板生成中的关键作用

Matthew P McCormack,Mark A Hall, Simone M Schoenwaelder, Quan Zhao, Sarah Ellis, Julia A Prentice, Ashleigh J Clarke, Nicholas J Slater, Jessica M Salmon, Shaun P Jackson, Stephen M Jane, David J Curtis

The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development

LMO2 T 细胞致癌基因在基因治疗期间通过染色体易位或逆转录病毒插入被激活,但在正常 T 细胞发育中没有强制性作用

Matthew P McCormack, Alan Forster, Lesley Drynan, Richard Pannell, Terence H Rabbitts