日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

适应性强的血流动力学内皮细胞在器官发生和肿瘤发生中的作用

Brisa Palikuqi ,Duc-Huy T Nguyen ,Ge Li ,Ryan Schreiner ,Alessandro F Pellegata ,Ying Liu ,David Redmond ,Fuqiang Geng ,Yang Lin ,Jesus M Gómez-Salinero ,Masataka Yokoyama ,Paul Zumbo ,Tuo Zhang ,Balvir Kunar ,Mavee Witherspoon ,Teng Han ,Alfonso M Tedeschi ,Federico Scottoni ,Steven M Lipkin ,Lukas Dow ,Olivier Elemento ,Jenny Z Xiang ,Koji Shido ,Jason R Spence ,Qiao J Zhou ,Robert E Schwartz ,Paolo De Coppi ,Sina Y Rabbany ,Shahin Rafii

ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer

ETHE1 过表达促进 SIRT1 和 PGC1α 介导的有氧糖酵解、氧化磷酸化、线粒体生物合成和结直肠癌

Mavee Witherspoon #, Davinder Sandu #, Changyuan Lu, Kehui Wang, Robert Edwards, Anthony Yeung, Ozkan Gelincik, Giovanni Manfredi, Steven Gross, Levy Kopelovich, Steven Lipkin

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

利用人诱导多能干细胞构建结肠类器官,用于模拟结直肠癌和药物测试

Miguel Crespo ,Eduardo Vilar ,Su-Yi Tsai ,Kyle Chang ,Sadaf Amin ,Tara Srinivasan ,Tuo Zhang ,Nina H Pipalia ,Huanhuan Joyce Chen ,Mavee Witherspoon ,Miriam Gordillo ,Jenny Zhaoying Xiang ,Frederick R Maxfield ,Steven Lipkin ,Todd Evans ,Shuibing Chen

A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal

肠道干细胞微环境内的 Notch 正反馈对于干细胞自我更新至关重要

Kai-Yuan Chen, Tara Srinivasan, Kuei-Ling Tung, Julio M Belmonte, Lihua Wang, Preetish Kadur Lakshminarasimha Murthy, Jiahn Choi, Nikolai Rakhilin, Sarah King, Anastasia Kristine Varanko, Mavee Witherspoon, Nozomi Nishimura, James A Glazier, Steven M Lipkin, Pengcheng Bu, Xiling Shen

Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine

无偏代谢物分析表明,胸苷池减少是α-二氟甲基鸟氨酸预防结肠癌的潜在机制。

Witherspoon, Mavee; Chen, Qiuying; Kopelovich, Levy; Gross, Steven S; Lipkin, Steven M

A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells

miR-34a调控的双模开关靶向结肠癌干细胞中的Notch信号通路

Bu, Pengcheng; Chen, Kai-Yuan; Chen, Joyce Huan; Wang, Lihua; Walters, Jewell; Shin, Yong Jun; Goerger, Julian P; Sun, Jian; Witherspoon, Mavee; Rakhilin, Nikolai; Li, Jiahe; Yang, Herman; Milsom, Jeff; Lee, Sang; Zipfel, Warren; Jin, Moonsoo M; Gümüş, Zeynep H; Lipkin, Steven M; Shen, Xiling

Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.

抑制 PRC2 组蛋白甲基转移酶活性可提高人结肠癌细胞对 TRAIL 介导的细胞凋亡的敏感性

Benoit Yannick D, Laursen Kristian B, Witherspoon Mavee S, Lipkin Steven M, Gudas Lorraine J

Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells

药理学抑制多梳抑制复合物-2 活性可诱导人类结肠癌干细胞凋亡

Yannick D Benoit, Mavee S Witherspoon, Kristian B Laursen, Amel Guezguez, Marco Beauséjour, Jean-Francois Beaulieu, Steven M Lipkin, Lorraine J Gudas

Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer

炎症性肠病相关结直肠癌中炎症和缺氧对 DNA 错配修复的表观遗传抑制

Robert A Edwards, Mavee Witherspoon, Kehui Wang, Kambiz Afrasiabi, Trang Pham, Lutz Birnbaumer, Steven M Lipkin

Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6'-N-acetyltransferase type Ib encoded by plasmid pJHCMW1

对质粒 pJHCMW1 编码的氨基糖苷 6'-N-乙酰转移酶 Ib 型中参与乙酰辅酶 A 结合的保守区域进行诱变分析

Pourreza, Atousa; Witherspoon, Mavee; Fox, Jessica; Newmark, Jason; Bui, Duyen; Tolmasky, Marcelo E