日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proteolysis-targeting chimeras with reduced off-targets

靶向蛋白水解的嵌合体,脱靶率较低

Tuan M Nguyen #, Vedagopuram Sreekanth #, Arghya Deb #, Praveen Kokkonda #, Praveen K Tiwari, Katherine A Donovan, Veronika Shoba, Santosh K Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary

Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7

利用来那度胺控制的膜结合可降解IL-7对CAR-T细胞中的细胞因子信号传导进行化学遗传控制

Michael C Kann ,Emily M Schneider ,Antonio J Almazan ,Isabel C Lane ,Amanda A Bouffard ,Valentina M Supper ,Hana N Takei ,Alexander Tepper ,Mark B Leick ,Rebecca C Larson ,Benjamin L Ebert ,Marcela V Maus ,Max Jan

Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma

分泌抗FAP/抗CD3分子的间皮素CAR T细胞可有效靶向胰腺腺癌及其间质

Marc Wehrli # ,Samantha Guinn # ,Filippo Birocchi # ,Adam Kuo ,Yi Sun ,Rebecca C Larson ,Antonio J Almazan ,Irene Scarfò ,Amanda A Bouffard ,Stefanie R Bailey ,Praju Vikas Anekal ,Paula Montero Llopis ,Linda T Nieman ,Yuhui Song ,Katherine H Xu ,Trisha R Berger ,Michael C Kann ,Mark B Leick ,Harrison Silva ,Diego Salas-Benito ,Tamina Kienka ,Korneel Grauwet ,Todd D Armstrong ,Rui Zhang ,Qingfeng Zhu ,Juan Fu ,Andrea Schmidts ,Felix Korell ,Max Jan ,Bryan D Choi ,Andrew S Liss ,Genevieve M Boland ,David T Ting ,Richard A Burkhart ,Russell W Jenkins ,Lei Zheng ,Elizabeth M Jaffee ,Jacquelyn W Zimmerman ,Marcela V Maus

Genetic retargeting of E3 ligases to enhance CAR T cell therapy

通过基因改造E3连接酶以增强CAR-T细胞疗法

Isabel C Lane ,Gabriele Kembuan ,Jeannie Carreiro ,Michael C Kann ,William Lin ,Amanda A Bouffard ,Johannes Kreuzer ,Robert Morris ,Emily M Schneider ,Joanna Y Kim ,Charles Zou ,Diego Salas-Benito ,Jessica A Gasser ,Mark B Leick ,Mikołaj Słabicki ,Wilhelm Haas ,Marcela V Maus ,Max Jan

A molecular glue approach to control the half-life of CRISPR-based technologies

一种控制 CRISPR 技术半衰期的分子胶水方法

Vedagopuram Sreekanth, Max Jan, Kevin T Zhao, Donghyun Lim, Jessie R Davis, Marie McConkey, Veronica Kovalcik, Sam Barkal, Benjamin K Law, James Fife, Ruilin Tian, Michael E Vinyard, Basheer Becerra, Martin Kampmann, Richard I Sherwood, Luca Pinello, David R Liu, Benjamin L Ebert, Amit Choudhary

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

与难治性 B 细胞淋巴瘤 CAR-T 疗法反应相关的独特细胞动力学

Nicholas J Haradhvala #, Mark B Leick #, Katie Maurer #, Satyen H Gohil #, Rebecca C Larson, Ning Yao, Kathleen M E Gallagher, Katelin Katsis, Matthew J Frigault, Jackson Southard, Shuqiang Li, Michael C Kann, Harrison Silva, Max Jan, Kahn Rhrissorrakrai, Filippo Utro, Chaya Levovitz, Raquel A Jacob

Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia

不可切割的铰链区增强了CAR-T细胞对急性髓系白血病的亲和力和扩增能力。

Mark B Leick ,Harrison Silva ,Irene Scarfò ,Rebecca Larson ,Bryan D Choi ,Amanda A Bouffard ,Kathleen Gallagher ,Andrea Schmidts ,Stefanie R Bailey ,Michael C Kann ,Max Jan ,Marc Wehrli ,Korneel Grauwet ,Nora Horick ,Matthew J Frigault ,Marcela V Maus

Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron

将损伤修复蛋白甲基鸟嘌呤甲基转移酶重新用作配体诱导融合蛋白

Gosia M Murawska, Caspar Vogel, Max Jan, Xinyan Lu, Matthias Schild, Mikolaj Slabicki, Charles Zou, Saule Zhanybekova, Manisha Manojkumar, Georg Petzold, Peter Kaiser, Nicolas Thomä, Benjamin Ebert, Dennis Gillingham

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

来那度胺控制的可逆ON和OFF开关嵌合抗原受体

Max Jan ,Irene Scarfò ,Rebecca C Larson ,Amanda Walker ,Andrea Schmidts ,Andrew A Guirguis ,Jessica A Gasser ,Mikołaj Słabicki ,Amanda A Bouffard ,Ana P Castano ,Michael C Kann ,Maria L Cabral ,Alexander Tepper ,Daniel E Grinshpun ,Adam S Sperling ,Taeyoon Kyung ,Quinlan L Sievers ,Michael E Birnbaum ,Marcela V Maus ,Benjamin L Ebert

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

CDK 抑制剂 CR8 可作为分子胶降解剂,消耗细胞周期蛋白 K

Mikołaj Słabicki #, Zuzanna Kozicka #, Georg Petzold #, Yen-Der Li, Manisha Manojkumar, Richard D Bunker, Katherine A Donovan, Quinlan L Sievers, Jonas Koeppel, Dakota Suchyta, Adam S Sperling, Emma C Fink, Jessica A Gasser, Li R Wang, Steven M Corsello, Rob S Sellar, Max Jan, Dennis Gillingham, Cla