日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Germline Single-Nucleotide Polymorphism GFI1-36N Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia

种系单核苷酸多态性 GFI1-36N 导致线粒体代谢改变,并在人类急性髓系白血病小鼠模型中导致 ROS 介导的 DNA 损伤增加。

Jan Vorwerk ,Longlong Liu ,Theresa Helene Stadler ,Daria Frank ,Helal Mohammed Mohammed Ahmed ,Pradeep Kumar Patnana ,Maxim Kebenko ,Eva Dazert ,Bertram Opalka ,Nikolas von Bubnoff ,Cyrus Khandanpour

A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors

一项针对难治性实体瘤患者的多中心 1 期临床试验,研究对象为双特异性 EpCAM/CD3 T 细胞接合剂 (BiTE®) 抗体构建体 solitomab (MT110, AMG 110)

Maxim Kebenko, Marie-Elisabeth Goebeler, Martin Wolf, Annette Hasenburg, Ruth Seggewiss-Bernhardt, Barbara Ritter, Beate Rautenberg, Djordje Atanackovic, Andrea Kratzer, James B Rottman, Matthias Friedrich, Eva Vieser, Stefanie Elm, Ingrid Patzak, Dorothea Wessiepe, Sabine Stienen, Walter Fiedler

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

GLI 和 FLT3 信号联合抑制可对人类急性髓系白血病产生有效的抗白血病作用

Emily-Marie Latuske, Hauke Stamm, Marianne Klokow, Gabi Vohwinkel, Jana Muschhammer, Carsten Bokemeyer, Manfred Jücker, Maxim Kebenko, Walter Fiedler, Jasmin Wellbrock