日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

在成年小鼠中消耗 Trim28 具有良好的耐受性,并可降低 α-突触核蛋白和 tau 的水平

Maxime Wc Rousseaux, Jean-Pierre Revelli, Gabriel E Vázquez-Vélez, Ji-Yoen Kim, Evelyn Craigen, Kristyn Gonzales, Jaclyn Beckinghausen, Huda Y Zoghbi

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

TRIM28 调节 α-突触核蛋白和 tau 的核积累和毒性

Maxime Wc Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Y Zoghbi

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

共济蛋白-1寡聚体可诱导病理的局部扩散,通过被动免疫减少这些寡聚体可减缓1型脊髓小脑性共济失调的表型。

Lasagna-Reeves, Cristian A; Rousseaux, Maxime Wc; Guerrero-Munoz, Marcos J; Vilanova-Velez, Luis; Park, Jeehye; See, Lauren; Jafar-Nejad, Paymaan; Richman, Ronald; Orr, Harry T; Kayed, Rakez; Zoghbi, Huda Y

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

天然相互作用蛋白可支撑并稳定 SCA1 中的有毒 ATAXIN-1 寡聚体

Cristian A Lasagna-Reeves, Maxime Wc Rousseaux, Marcos J Guerrero-Muñoz, Jeehye Park, Paymaan Jafar-Nejad, Ronald Richman, Nan Lu, Urmi Sengupta, Alexandra Litvinchuk, Harry T Orr, Rakez Kayed, Huda Y Zoghbi