日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Targeting phosphodiesterase 10A disrupts MAPK signaling pathways in the tumor microenvironment to unleash antitumor immunity

靶向磷酸二酯酶10A可破坏肿瘤微环境中的MAPK信号通路，从而激活抗肿瘤免疫。

期刊:
影响因子:
doi:10.64898/2026.02.26.708383
Gazi, Md Y; Ye, Yan; Okoko, Ogacheko D; Wang, Xin; Simon, Samson E; Alimadadi, Ahmad; Suryawanshi, Nandeeni; Brandle, Catlin; Zheng, Mei; Pei, Lirong; Fadlalla, Khalda; Keeton, Adam; Maxuitenko, Yulia; Chen, Xi; Chiang, Austin W T; Schoenlein, Patricia; Lyu, Dongwen; Wolff, David; Hedrick, Catherine C; Shi, Huidong; Piazza, Gary; Zhou, Gang
信号转导
免疫/内分泌
肿瘤微环境
MAPK/ERK
肿瘤
肿瘤免疫
发表日期：2026
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ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂，在胰腺导管腺癌中表现出强大的抗肿瘤活性。

期刊:
影响因子:
doi:10.64898/2026.02.11.705411
Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Foote, Jeremy B; Keeton, Adam B; Chen, Xi; Ramirez-Alcantara, Veronica; Holmes, Thomas; Akce, Mehmet; Singh, Anju; Powell, Craig M; Behera, Santosh; Azmi, Asfar S; Nurmemmedov, Elmar; Babic, Ivan; Gorman, Gregory S; Coward, Lori; Buchsbaum, Donald J; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F
肿瘤
肿瘤免疫
PDE10
发表日期：2026
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ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004：一种首创的口服泛RAS抑制剂，在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02288-9
Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Carstens, Julienne L; Foote, Jeremy B; Graff, Emily C; Fang, Yu-Hua D; Keeton, Adam B; Chen, Xi; Valiyaveettil, Jacob; Berry, Kristy L; Bae, Sejong; Akce, Mehmet; Gorman, Greg; Yoon, Karina J; Manne, Upender; Boyd, Michael R; Buchsbaum, Donald J; Azmi, Asfar S; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F
RAS
肿瘤
肿瘤免疫
发表日期：2025
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A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

期刊:Cancer Research
影响因子:16.6
doi:10.1158/0008-5472.CAN-24-0323
Foote Jeremy B, Mattox Tyler E, Keeton Adam B, Chen Xi, Smith Forrest T, Berry Kristy, Holmes Thomas W, Wang Junwei, Huang Chung-Hui, Ward Antonio, Mitra Amit K, Ramirez-Alcantara Veronica, Hardy Cherlene, Fleten Karianne G, Flatmark Kjersti, Yoon Karina J, Sarvesh Sujith, Nagaraju Ganji P, Bandi Dhana Sekhar Reddy, Maxuitenko Yulia Y, Valiyaveettil Jacob, Carstens Julienne L, Buchsbaum Donald J, Yang Jennifer, Zhou Gang, Nurmemmedov Elmar, Babic Ivan, Gaponeko Vadim, Abdelkarim Hazem, Boyd Michael R, Gorman Greg, Manne Upender, Bae Sejong, El-Rayes Bassel F, Piazza Gary A
肿瘤
肿瘤免疫
发表日期：2025
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Evaluation of a Novel Pan-RAS Inhibitor in 3D Bioprinted Tumor Models

在3D生物打印肿瘤模型中评估一种新型泛RAS抑制剂

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers17182958
De Nobrega, Daniela D; Eiler, Logan C; Ahirwar, Parmanand; Nallapu, Sonika; Rawal, Urvi P; Crawford, Chelsea L; Buchsbaum, Donald J; Keeton, Adam B; Maxuitenko, Yulia Y; Chen, Xi; Piazza, Gary A; Tsung, Allan; Budhwani, Karim I
3D/类器官
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia.

高特异性免疫蛋白酶体抑制剂 M3258 可诱导 KMT2A::AFF1 驱动的急性淋巴细胞白血病中的蛋白毒性应激和细胞凋亡

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-01657-0
Jenkins Tyler W, Fitzgerald Jacquelyn Elise, Park Jieun, Wilson Addison M, Berry Kristy L, Wong Keith S, Houry Walid A, Lee Irene, Maksimenko Andrey V, Panizzi Peter R, Maxuitenko Yulia Y, Loop Matthew Shane, Mitra Amit K, Kisselev Alexei F
细胞生物学
白血病
凋亡
发表日期：2025
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Potency and selectivity of a novel pan-RAS inhibitor in 3D bioprinted organoid tumor models

新型泛RAS抑制剂在3D生物打印类器官肿瘤模型中的效力和选择性

期刊:
影响因子:
doi:10.1101/2025.02.25.640132
De Nobrega, Daniela; Eiler, Logan C; Ahirwar, Parmanand; Rawal, Urvi P; Crawford, Chelsea L; Buchsbaum, Donald J; Keeton, Adam B; Maxuitenko, Yulia Y; Chen, Xi; Piazza, Gary A; Tsung, Allan; Budhwani, Karim I
3D/类器官
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Assessment of KRAS(G12C) inhibitors for colorectal cancer

评估KRAS(G12C)抑制剂在结直肠癌中的应用

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2024.1412435
Piazza, Gary A; Chandrasekaran, Preethi; Maxuitenko, Yulia Y; Budhwani, Karim I
RAS
肿瘤
肠癌
肿瘤免疫
发表日期：2024
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Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

新型非环氧合酶抑制舒林酸衍生物可抑制乳腺癌细胞体外生长并降低大鼠乳腺肿瘤发生率

期刊:Cancers
影响因子:
doi:10.3390/cancers15030646
Heather N Tinsley, Bini Mathew, Xi Chen, Yulia Y Maxuitenko, Nan Li, Whitney M Lowe, Jason D Whitt, Wei Zhang, Bernard D Gary, Adam B Keeton, William E Grizzle, Clinton J Grubbs, Robert C Reynolds, Gary A Piazza
肿瘤
乳腺癌
肿瘤细胞
发表日期：2023
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PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

PDE5 和 PDE10 抑制剂可激活 cGMP/PKG 信号通路，从而阻断 Wnt/β-catenin 转录、癌细胞生长和肿瘤免疫。

期刊:Drug Discovery Today
影响因子:7.5
doi:10.1016/j.drudis.2020.06.008
Piazza, Gary A; Ward, Antonio; Chen, Xi; Maxuitenko, Yulia; Coley, Alex; Aboelella, Nada S; Buchsbaum, Donald J; Boyd, Michael R; Keeton, Adam B; Zhou, Gang
信号转导
免疫/内分泌
肿瘤
PDE10
Wnt/β-Catenin
细胞生物学
肿瘤免疫
发表日期：2020
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