日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂，在胰腺导管腺癌中表现出强大的抗肿瘤活性。

期刊:
影响因子:
doi:10.64898/2026.02.11.705411
Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Foote, Jeremy B; Keeton, Adam B; Chen, Xi; Ramirez-Alcantara, Veronica; Holmes, Thomas; Akce, Mehmet; Singh, Anju; Powell, Craig M; Behera, Santosh; Azmi, Asfar S; Nurmemmedov, Elmar; Babic, Ivan; Gorman, Gregory S; Coward, Lori; Buchsbaum, Donald J; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F
肿瘤
肿瘤免疫
PDE10
发表日期：2026
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ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004：一种首创的口服泛RAS抑制剂，在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02288-9
Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Carstens, Julienne L; Foote, Jeremy B; Graff, Emily C; Fang, Yu-Hua D; Keeton, Adam B; Chen, Xi; Valiyaveettil, Jacob; Berry, Kristy L; Bae, Sejong; Akce, Mehmet; Gorman, Greg; Yoon, Karina J; Manne, Upender; Boyd, Michael R; Buchsbaum, Donald J; Azmi, Asfar S; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F
RAS
肿瘤
肿瘤免疫
发表日期：2025
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A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

期刊:Cancer Research
影响因子:16.6
doi:10.1158/0008-5472.CAN-24-0323
Foote Jeremy B, Mattox Tyler E, Keeton Adam B, Chen Xi, Smith Forrest T, Berry Kristy, Holmes Thomas W, Wang Junwei, Huang Chung-Hui, Ward Antonio, Mitra Amit K, Ramirez-Alcantara Veronica, Hardy Cherlene, Fleten Karianne G, Flatmark Kjersti, Yoon Karina J, Sarvesh Sujith, Nagaraju Ganji P, Bandi Dhana Sekhar Reddy, Maxuitenko Yulia Y, Valiyaveettil Jacob, Carstens Julienne L, Buchsbaum Donald J, Yang Jennifer, Zhou Gang, Nurmemmedov Elmar, Babic Ivan, Gaponeko Vadim, Abdelkarim Hazem, Boyd Michael R, Gorman Greg, Manne Upender, Bae Sejong, El-Rayes Bassel F, Piazza Gary A
肿瘤
肿瘤免疫
发表日期：2025
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Evaluation of a Novel Pan-RAS Inhibitor in 3D Bioprinted Tumor Models

在3D生物打印肿瘤模型中评估一种新型泛RAS抑制剂

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers17182958
De Nobrega, Daniela D; Eiler, Logan C; Ahirwar, Parmanand; Nallapu, Sonika; Rawal, Urvi P; Crawford, Chelsea L; Buchsbaum, Donald J; Keeton, Adam B; Maxuitenko, Yulia Y; Chen, Xi; Piazza, Gary A; Tsung, Allan; Budhwani, Karim I
3D/类器官
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia.

高特异性免疫蛋白酶体抑制剂 M3258 可诱导 KMT2A::AFF1 驱动的急性淋巴细胞白血病中的蛋白毒性应激和细胞凋亡

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-01657-0
Jenkins Tyler W, Fitzgerald Jacquelyn Elise, Park Jieun, Wilson Addison M, Berry Kristy L, Wong Keith S, Houry Walid A, Lee Irene, Maksimenko Andrey V, Panizzi Peter R, Maxuitenko Yulia Y, Loop Matthew Shane, Mitra Amit K, Kisselev Alexei F
细胞生物学
白血病
凋亡
发表日期：2025
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Potency and selectivity of a novel pan-RAS inhibitor in 3D bioprinted organoid tumor models

新型泛RAS抑制剂在3D生物打印类器官肿瘤模型中的效力和选择性

期刊:
影响因子:
doi:10.1101/2025.02.25.640132
De Nobrega, Daniela; Eiler, Logan C; Ahirwar, Parmanand; Rawal, Urvi P; Crawford, Chelsea L; Buchsbaum, Donald J; Keeton, Adam B; Maxuitenko, Yulia Y; Chen, Xi; Piazza, Gary A; Tsung, Allan; Budhwani, Karim I
3D/类器官
RAS
肿瘤
肿瘤免疫
发表日期：2025
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Assessment of KRAS(G12C) inhibitors for colorectal cancer

评估KRAS(G12C)抑制剂在结直肠癌中的应用

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2024.1412435
Piazza, Gary A; Chandrasekaran, Preethi; Maxuitenko, Yulia Y; Budhwani, Karim I
RAS
肿瘤
肠癌
肿瘤免疫
发表日期：2024
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Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

利用RAS核苷酸循环作为RAS驱动型癌症的药物治疗策略

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms21010141
Mattox, Tyler E; Chen, Xi; Maxuitenko, Yulia Y; Keeton, Adam B; Piazza, Gary A
RAS
肿瘤
肿瘤免疫
发表日期：2019
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Establishment of a mammary carcinoma cell line from Syrian hamsters treated with N-methyl-N-nitrosourea

利用N-甲基-N-亚硝基脲处理叙利亚仓鼠，建立乳腺癌细胞系

期刊:Cancer Letters
影响因子:10.1
doi:10.1016/j.canlet.2011.08.003
Coburn, Malari A; Brueggemann, Sabrina; Bhatia, Shilpa; Cheng, Bing; Li, Benjamin D L; Li, Xiao-Lin; Luraguiz, Natalia; Maxuitenko, Yulia Y; Orchard, Elysse A; Zhang, Songlin; Stoff-Khalili, Mariam A; Mathis, J Michael; Kleiner-Hancock, Heather E
细胞生物学
肿瘤
肿瘤免疫
乳腺癌
发表日期：2011
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Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition

舒林酸硫化物和其他非甾体抗炎药对结肠肿瘤细胞生长的抑制作用与磷酸二酯酶5的抑制有关。

期刊:Cancer Prevention Research
影响因子:2.6
doi:10.1158/1940-6207.CAPR-10-0030
Tinsley, Heather N; Gary, Bernard D; Thaiparambil, Jose; Li, Nan; Lu, Wenyan; Li, Yonghe; Maxuitenko, Yulia Y; Keeton, Adam B; Piazza, Gary A
肿瘤细胞
细胞生物学
肿瘤
肿瘤免疫
发表日期：2010
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