日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders

Drugit:众包非肽类VHL结合剂的分子设计

Scott, Thomas; Smethurst, Christian Alan Paul; Westermaier, Yvonne; Mayer, Moriz; Greb, Peter; Kousek, Roland; Biberger, Tobias; Bader, Gerd; Jandova, Zuzana; Schmalhorst, Philipp S; Fuchs, Julian E; Magarkar, Aniket; Hoenke, Christoph; Gerstberger, Thomas; Combs, Steven A; Pape, Richard; Phul, Saksham; Kothiwale, Sandeepkumar; Bergner, Andreas; Waterson, Alex G; Weinstabl, Harald; McConnell, Darryl B; Meiler, Jens; Böttcher, Jark; Moretti, Rocco

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

发现 BI-2493,一种泛 KRAS 抑制剂,显示出体内疗效

Bröker Joachim, Waterson Alex G, Hodges Timothy R, Abbott Jason R, Arnold Allison, Böttcher Jark, Braun Nina, Cui Jianwen, Fuchs Julian E, Gerstberger Thomas, Gogg Sebastian, Hanner Sabine, Herdeis Lorenz, Howell Lucas W, Mantoulidis Andreas, Mayer Moriz, Phan Jason, Rocchetti Francesca, Sankar Kyra, Sarkar Dhruba, Schaaf Otmar, Sensintaffar John L, Sun Qi, Wunberg Tobias, Fesik Stephen W

NMR-driven structure-based drug discovery by unveiling molecular interactions

通过揭示分子相互作用,利用核磁共振驱动的基于结构的药物发现

Platzer, Gerald; Mayer, Moriz; McConnell, Darryl B; Konrat, Robert

Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups

通过选择性标记甲基的化学位移测量来探测蛋白质-配体甲基-π相互作用几何结构

Beier, Andreas; Platzer, Gerald; Höfurthner, Theresa; Ptaszek, Aleksandra L; Lichtenecker, Roman J; Geist, Leonhard; Fuchs, Julian E; McConnell, Darryl B; Mayer, Moriz; Konrat, Robert

Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays.

追逐虚假信号:钯金属盐杂质在生化测定中伪装成 KRAS 活性

Gerstberger Thomas, Berger Helmut, Büttner Frank H, Gmachl Michael, Kessler Dirk, Koegl Manfred, Lucas Simon, Martin Laetitia J, Mayer Moriz, McConnell Darryl B, Mitzner Sophie, Scholz Guido, Treu Matthias, Wolkerstorfer Bernhard, Zahn Stephan, Zak Krzysztof M, Jaeger Philipp A, Ettmayer Peter

Synthesis of a (13)C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics

合成(13)C-亚甲基标记的异亮氨酸前体作为研究蛋白质侧链相互作用和动力学的有用工具

Höfurthner, Theresa; Toscano, Giorgia; Kontaxis, Georg; Beier, Andreas; Mayer, Moriz; Geist, Leonhard; McConnell, Darryl B; Weinstabl, Harald; Lichtenecker, Roman; Konrat, Robert

Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods

有效控制未受药物影响的疾病:利用基于片段的方法靶向β-catenin

Kessler, Dirk; Mayer, Moriz; Zahn, Stephan K; Zeeb, Markus; Wöhrle, Simon; Bergner, Andreas; Bruchhaus, Jens; Ciftci, Tuncay; Dahmann, Georg; Dettling, Maike; Döbel, Sandra; Fuchs, Julian E; Geist, Leonhard; Hela, Wolfgang; Kofink, Christiane; Kousek, Roland; Moser, Franziska; Puchner, Teresa; Rumpel, Klaus; Scharnweber, Maximilian; Werni, Patrick; Wolkerstorfer, Bernhard; Breitsprecher, Dennis; Baaske, Philipp; Pearson, Mark; McConnell, Darryl B; Böttcher, Jark

PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy

利用核磁共振波谱法探测蛋白质-配体复合物中的CH-π相互作用

Platzer, Gerald; Mayer, Moriz; Beier, Andreas; Brüschweiler, Sven; Fuchs, Julian E; Engelhardt, Harald; Geist, Leonhard; Bader, Gerd; Schörghuber, Julia; Lichtenecker, Roman; Wolkerstorfer, Bernhard; Kessler, Dirk; McConnell, Darryl B; Konrat, Robert

Drugging an undruggable pocket on KRAS

对 KRAS 上的一个无法用药的口袋进行药物治疗

Kessler, Dirk; Gmachl, Michael; Mantoulidis, Andreas; Martin, Laetitia J; Zoephel, Andreas; Mayer, Moriz; Gollner, Andreas; Covini, David; Fischer, Silke; Gerstberger, Thomas; Gmaschitz, Teresa; Goodwin, Craig; Greb, Peter; Häring, Daniela; Hela, Wolfgang; Hoffmann, Johann; Karolyi-Oezguer, Jale; Knesl, Petr; Kornigg, Stefan; Koegl, Manfred; Kousek, Roland; Lamarre, Lyne; Moser, Franziska; Munico-Martinez, Silvia; Peinsipp, Christoph; Phan, Jason; Rinnenthal, Jörg; Sai, Jiqing; Salamon, Christian; Scherbantin, Yvonne; Schipany, Katharina; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Siszler, Gabriella; Sun, Qi; Waterson, Alex; Wolkerstorfer, Bernhard; Zeeb, Markus; Pearson, Mark; Fesik, Stephen W; McConnell, Darryl B