日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice

突变朊病毒蛋白增强NMDA受体活性,激活蛋白激酶C (PKC),并在小鼠中引发快速兴奋性毒性。

Lin, Joie; Callender, Julia A; Mayfield, Joshua E; McClatchy, Daniel B; Ojeda-Juárez, Daniel; Pourhamzeh, Mahsa; Soldau, Katrin; Kurt, Timothy D; Danque, Garrett A; Khuu, Helen; Ronson, Josephina E; Pizzo, Donald P; Du, Yixing; Gruber, Maxwell A; Sevillano, Alejandro M; Wang, Jin; Orrú, Christina D; Chen, Joy; Funk, Gail; Aguilar-Calvo, Patricia; Aulston, Brent D; Roy, Subhojit; Rho, Jong M; Bui, Jack D; Newton, Alexandra C; Lipton, Stuart A; Caughey, Byron; Patrick, Gentry N; Doré, Kim; Yates, John R 3rd; Sigurdson, Christina J

A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.

PKCη错义突变增强了高尔基体定位的信号传导,并且与隐性遗传的家族性阿尔茨海默病有关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

Multi-omic analysis of meningeal cerebral amyloid angiopathy reveals enrichment of unsubstituted glucosamine and extracellular proteins.

脑膜淀粉样血管病的多组学分析显示未取代的葡萄糖胺和细胞外蛋白富集

Mayfield Joshua E, Rajic Alexander J, Aguilar-Calvo Patricia, Soldau Katrin, Flores Samantha, Lawrence Roger, Choudhury Biwsa, Ghassemian Majid, Pizzo Donald P, Wagner Steven L, Danque Garrett A, Sumowski Paige, Hansen Lawrence A, Goodwill Vanessa, Esko Jeffery D, Sigurdson Christina J

Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.

蛋白激酶 C eta 可增强高尔基体定位的信号传导,并以隐性遗传方式与阿尔茨海默病相关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice

种系饱和诱变诱导小鼠骨骼表型

Rios, Jonathan J; Denton, Kristin; Russell, Jamie; Kozlitina, Julia; Ferreira, Carlos R; Lewanda, Amy F; Mayfield, Joshua E; Moresco, Eva; Ludwig, Sara; Tang, Miao; Li, Xiaohong; Lyon, Stephen; Khanshour, Anas; Paria, Nandina; Khalid, Aysha; Li, Yang; Xie, Xudong; Feng, Jian Q; Xu, Qian; Lu, Yongbo; Hammer, Robert E; Wise, Carol A; Beutler, Bruce

Structural Motifs for CTD Kinase Specificity on RNA Polymerase II during Eukaryotic Transcription

真核转录过程中 RNA 聚合酶 II 上 CTD 激酶特异性的结构基序

Ramani, Mukesh Kumar Venkat; Escobar, Edwin E; Irani, Seema; Mayfield, Joshua E; Moreno, Rosamaria Y; Butalewicz, Jamie P; Cotham, Victoria C; Wu, Haoyi; Tadros, Meena; Brodbelt, Jennifer S; Zhang, Yan Jessie

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

双特异性酪氨酸磷酸化调节激酶2的抑制会扰乱26S蛋白酶体依赖的肿瘤进展。

Banerjee, Sourav; Wei, Tiantian; Wang, Jue; Lee, Jenna J; Gutierrez, Haydee L; Chapman, Owen; Wiley, Sandra E; Mayfield, Joshua E; Tandon, Vasudha; Juarez, Edwin F; Chavez, Lukas; Liang, Ruqi; Sah, Robert L; Costello, Caitlin; Mesirov, Jill P; de la Vega, Laureano; Cooper, Kimberly L; Dixon, Jack E; Xiao, Junyu; Lei, Xiaoguang

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

古代药物姜黄素通过直接抑制双特异性酪氨酸调节激酶2来阻碍26S蛋白酶体的活性

Banerjee, Sourav; Ji, Chenggong; Mayfield, Joshua E; Goel, Apollina; Xiao, Junyu; Dixon, Jack E; Guo, Xing

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

固有无序的RNA聚合酶II C端结构域的结构异质性

Portz, Bede; Lu, Feiyue; Gibbs, Eric B; Mayfield, Joshua E; Rachel Mehaffey, M; Zhang, Yan Jessie; Brodbelt, Jennifer S; Showalter, Scott A; Gilmour, David S

Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry

利用紫外光解离质谱法绘制果蝇RNA聚合酶II羧基末端结构域的磷酸化模式

Mayfield, Joshua E; Robinson, Michelle R; Cotham, Victoria C; Irani, Seema; Matthews, Wendy L; Ram, Anjana; Gilmour, David S; Cannon, Joe R; Zhang, Yan Jessie; Brodbelt, Jennifer S