日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Exploring Resilience Among Survivors of Domestic and Intimate Partner Violence in Rural Canada

探索加拿大农村地区家庭暴力和亲密伴侣暴力幸存者的韧性

Holtmann, Cathy; Lefurgey, Mayme

Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model

发现具有强效细胞活性和在小鼠实体瘤异种移植模型中体内活性的巨环髓系细胞白血病1 (Mcl-1) 抑制剂

Tarr, James C; Jeon, Kyuok; Veerasamy, Nagarathanam; Aichinger, Martin; Salovich, James M; Zhao, Bin; Sensintaffar, John L; Arnhof, Heribert; Wunberg, Tobias; Sgubin, Danielle; Arnold, Allison; Vekariya, Rakesh H; Christov, Plamen P; Kim, Kwangho; Fuchs, Julian Emanuel; Karier, Pol; Betzemeier, Bodo; Van Meveren, Mayme; Miriyala, Nagaraju; Olejniczak, Edward T; Engelhardt, Harald; Lee, Taekyu; McConnell, Darryl; Fesik, Stephen W

Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer

逆转乳酸和PD-1介导的巨噬细胞免疫抑制可控制PTEN/p53缺陷型前列腺癌的生长

Kiranj Chaudagar ,Hanna M Hieromnimon # ,Rimpi Khurana # ,Brian Labadie ,Taghreed Hirz ,Shenglin Mei ,Raisa Hasan ,Jordan Shafran ,Anne Kelley ,Eva Apostolov ,Ghamdan Al-Eryani ,Kate Harvey ,Srikrishnan Rameshbabu ,Mayme Loyd ,Kaela Bynoe ,Catherine Drovetsky ,Ani Solanki ,Erica Markiewicz ,Marta Zamora ,Xiaobing Fan ,Stephan Schürer ,Alex Swarbrick ,David B Sykes ,Akash Patnaik

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

基于结构的高效WD重复结构域5抑制剂的发现,在临床前动物模型中证实了其疗效和安全性。

Teuscher, Kevin B; Chowdhury, Somenath; Meyers, Kenneth M; Tian, Jianhua; Sai, Jiqing; Van Meveren, Mayme; South, Taylor M; Sensintaffar, John L; Rietz, Tyson A; Goswami, Soumita; Wang, Jing; Grieb, Brian C; Lorey, Shelly L; Howard, Gregory C; Liu, Qi; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W

Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors

基于结构的高效、口服生物利用度高的苯并唑酮类WD重复结构域5抑制剂的发现

Teuscher, Kevin B; Mills, Jonathan J; Tian, Jianhua; Han, Changho; Meyers, Kenneth M; Sai, Jiqing; South, Taylor M; Crow, Mackenzie M; Van Meveren, Mayme; Sensintaffar, John L; Zhao, Bin; Amporndanai, Kangsa; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W

Aortic valve leaflets are asymmetric and correlated with the origin of coronary arteries

主动脉瓣叶不对称,且与冠状动脉的起源相关。

Koerner, Taylor S; Cunningham, Thomas; Marshall, Mayme E; Talley, Lauren S; Childress, Megan; Kharouf, Rami M; Li, Wen; Salazar, Jorge D; Corno, Antonio F

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

雄激素阻断可激活巨噬细胞中的NLRP3,从而诱导肿瘤吞噬作用。

Chaudagar, Kiranj; Rameshbabu, Srikrishnan; Mei, Shenglin; Hirz, Taghreed; Hu, Ya-Mei; Argulian, Anna; Labadie, Brian; Desai, Kunal; Grimaldo, Sam; Kahramangil, Doga; Nair, Rishikesh; DSouza, Sabina; Zhou, Dylan; Li, Mingyang; Doughan, Farah; Chen, Raymond; Shafran, Jordan; Loyd, Mayme; Xia, Zheng; Sykes, David B; Moran, Amy; Patnaik, Akash

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021

2018-2021年ST段抬高型心肌梗死患者的治疗时间和院内死亡率

Jollis, James G; Granger, Christopher B; Zègre-Hemsey, Jessica K; Henry, Timothy D; Goyal, Abhinav; Tamis-Holland, Jacqueline E; Roettig, Mayme Lou; Ali, Murtuza J; French, William J; Poudel, Ram; Zhao, Juan; Stone, R Harper; Jacobs, Alice K

A Water Extract from Chlorella sorokiniana Cell Walls Stimulates Growth of Bone Marrow Cells and Splenocytes

小球藻细胞壁水提取物可刺激骨髓细胞和脾细胞的生长

Ishiguro, Susumu; Roth, Mary; Welti, Ruth; Loyd, Mayme; Thakkar, Ravindra; Phillips, Morgan; Robben, Nicole; Upreti, Deepa; Nakashima, Ayaka; Suzuki, Kengo; Comer, Jeffrey; Tamura, Masaaki

Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice

利用编码新型PD-L1抑制肽的腺病毒进行局部免疫检查点阻断治疗,可抑制免疫功能正常小鼠结肠癌的生长。

Susumu Ishiguro ,Deepa Upreti ,Molly Bassette ,E R Azhagiya Singam ,Ravindra Thakkar ,Mayme Loyd ,Makoto Inui ,Jeffrey Comer ,Masaaki Tamura