日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
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2025
2026
影响因子:
–

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

延长小鼠寿命的多种干预措施抑制了关键基因调控区域中与年龄相关的共同表观遗传变化。

期刊:Genome Biology
影响因子:9.4
doi:10.1186/s13059-017-1185-3
Cole, John J; Robertson, Neil A; Rather, Mohammed Iqbal; Thomson, John P; McBryan, Tony; Sproul, Duncan; Wang, Tina; Brock, Claire; Clark, William; Ideker, Trey; Meehan, Richard R; Miller, Richard A; Brown-Borg, Holly M; Adams, Peter D
信号转导
表观遗传
发表日期：2017
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Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function

表达癌基因的衰老黑素细胞上调MHC II类分子，MHC II类分子可能具有黑色素瘤抑制功能。

期刊:Journal of Investigative Dermatology
影响因子:5.7
doi:10.1016/j.jid.2017.05.030
van Tuyn, John; Jaber-Hijazi, Farah; MacKenzie, Douglas; Cole, John J; Mann, Elizabeth; Pawlikowski, Jeff S; Rai, Taranjit Singh; Nelson, David M; McBryan, Tony; Ivanov, Andre; Blyth, Karen; Wu, Hong; Milling, Simon; Adams, Peter D
黑色素瘤
肿瘤
肿瘤免疫
衰老
细胞生物学
发表日期：2017
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Senescent cells harbour features of the cancer epigenome

衰老细胞具有癌症表观基因组的特征。

期刊:Nature Cell Biology
影响因子:19.1
doi:10.1038/ncb2879
Cruickshanks, Hazel A; McBryan, Tony; Nelson, David M; Vanderkraats, Nathan D; Shah, Parisha P; van Tuyn, John; Singh Rai, Taranjit; Brock, Claire; Donahue, Greg; Dunican, Donncha S; Drotar, Mark E; Meehan, Richard R; Edwards, John R; Berger, Shelley L; Adams, Peter D
肿瘤
表观遗传
肿瘤免疫
衰老
细胞生物学
发表日期：2013
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Wnt signaling potentiates nevogenesis

Wnt信号通路促进痣的发生

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1303491110
Pawlikowski, Jeff S; McBryan, Tony; van Tuyn, John; Drotar, Mark E; Hewitt, Rachael N; Maier, Andrea B; King, Ayala; Blyth, Karen; Wu, Hong; Adams, Peter D
信号转导
Wnt/β-Catenin
发表日期：2013
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Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

PIK3CA/AKT通路激活可抑制RAS癌基因激活诱导的衰老，从而促进肿瘤发生。

期刊:Molecular Cell
影响因子:16.6
doi:10.1016/j.molcel.2011.02.020
Kennedy, Alyssa L; Morton, Jennifer P; Manoharan, Indrani; Nelson, David M; Jamieson, Nigel B; Pawlikowski, Jeff S; McBryan, Tony; Doyle, Brendan; McKay, Colin; Oien, Karin A; Enders, Greg H; Zhang, Rugang; Sansom, Owen J; Adams, Peter D
肿瘤
肿瘤免疫
信号转导
衰老
RAS
AKT
发表日期：2011
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Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.

衰老的小鼠细胞无法明显调节 HIRA 组蛋白伴侣，也无法形成稳定的衰老相关异染色质灶

期刊:Cell Division
影响因子:2.2
doi:10.1186/1747-1028-5-16
Kennedy Alyssa L, McBryan Tony, Enders Greg H, Johnson F Brad, Zhang Rugang, Adams Peter D
细胞生物学
Mouse
发表日期：2010
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