日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Momelotinib: Mechanism of action, clinical, and translational science

莫美替尼:作用机制、临床和转化科学

Vlasakakis, Georgios; McCabe, Michael T; Ho, Yu Liu; Ferron-Brady, Geraldine; Martin, Paul; Bentley, Darren; Ellis, Catherine; Antonysamy, Mary; Visser, Sandra A G

A Phase I/II Open-Label Study of Molibresib for the Treatment of Relapsed/Refractory Hematologic Malignancies

一项针对复发/难治性血液系统恶性肿瘤的 Molibresib I/II 期开放标签研究

Dawson, Mark A; Borthakur, Gautam; Huntly, Brian J P; Karadimitris, Anastasios; Alegre, Adrian; Chaidos, Aristeidis; Vogl, Dan T; Pollyea, Daniel A; Davies, Faith E; Morgan, Gareth J; Glass, Jacob L; Kamdar, Manali; Mateos, Maria-Victoria; Tovar, Natalia; Yeh, Paul; Delgado, Regina García; Basheer, Faisal; Marando, Ludovica; Gallipoli, Paolo; Wyce, Anastasia; Krishnatry, Anu Shilpa; Barbash, Olena; Bakirtzi, Evi; Ferron-Brady, Geraldine; Karpinich, Natalie O; McCabe, Michael T; Foley, Shawn W; Horner, Thierry; Dhar, Arindam; Kremer, Brandon E; Dickinson, Michael

PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.

癌症中的 PRC2 失活突变通过增强病毒模拟来增强对 DNMT1 靶向治疗的细胞毒性反应

Patel Amish J, Warda Sarah, Maag Jesper L V, Misra Rohan, Miranda-Román Miguel A, Pachai Mohini R, Lee Cindy J, Li Dan, Wang Naitao, Bayshtok Gabriella, Fishinevich Eve, Meng Yinuo, Wong Elissa W P, Yan Juan, Giff Emily, Pappalardi Melissa B, McCabe Michael T, Fletcher Jonathan A, Rudin Charles M, Chandarlapaty Sarat, Scandura Joseph M, Koche Richard P, Glass Jacob L, Antonescu Cristina R, Zheng Deyou, Chen Yu, Chi Ping

Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors

含二氰基吡啶的DNMT1选择性非核苷类抑制剂的结构表征

Horton, John R; Pathuri, Sarath; Wong, Kristen; Ren, Ren; Rueda, Lourdes; Fosbenner, David T; Heerding, Dirk A; McCabe, Michael T; Pappalardi, Melissa B; Zhang, Xing; King, Bryan W; Cheng, Xiaodong

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

利用可逆选择性DNMT1抑制剂在体外和体内诱导胎儿血红蛋白的产生

Gilmartin, Aidan G; Groy, Arthur; Gore, Elizabeth R; Atkins, Charity; Long, Edward R; Montoute, Monica N; Wu, Zining; Halsey, Wendy; McNulty, Dean E; Ennulat, Daniela; Rueda, Lourdes; Pappalardi, Melissa; Kruger, Ryan G; McCabe, Michael T; Raoof, Ali; Butlin, Roger; Stowell, Alexandra; Cockerill, Mark; Waddell, Ian; Ogilvie, Donald; Luengo, Juan; Jordan, Allan; Benowitz, Andrew B

Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors

新型增强子Zeste同源物2 (EZH2) 抑制剂GSK2816126治疗晚期血液肿瘤和实体瘤患者的I期研究

Yap, Timothy A; Winter, Jane N; Giulino-Roth, Lisa; Longley, Jemma; Lopez, Juanita; Michot, Jean-Marie; Leonard, John P; Ribrag, Vincent; McCabe, Michael T; Creasy, Caretha L; Stern, Melissa; Pene Dumitrescu, Teodora; Wang, Xiaowei; Frey, Steve; Carver, Jennifer; Horner, Thierry; Oh, Choon; Khaled, Ahmed; Dhar, Arindam; Johnson, Peter W M

MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers

MEK抑制剂能够克服多种实体瘤和血液肿瘤对BET抑制剂的耐药性。

Wyce, Anastasia; Matteo, Jeanne J; Foley, Shawn W; Felitsky, Daniel J; Rajapurkar, Satyajit R; Zhang, Xi-Ping; Musso, Melissa C; Korenchuk, Susan; Karpinich, Natalie O; Keenan, Kathryn M; Stern, Melissa; Mathew, Lijoy K; McHugh, Charles F; McCabe, Michael T; Tummino, Peter J; Kruger, Ryan G; Carpenter, Christopher; Barbash, Olena

BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models

BET抑制剂可沉默MYCN和BCL2的表达,并在神经母细胞瘤模型中诱导细胞毒性。

Wyce, Anastasia; Ganji, Gopinath; Smitheman, Kimberly N; Chung, Chun-Wa; Korenchuk, Susan; Bai, Yuchen; Barbash, Olena; Le, BaoChau; Craggs, Peter D; McCabe, Michael T; Kennedy-Wilson, Karen M; Sanchez, Lydia V; Gosmini, Romain L; Parr, Nigel; McHugh, Charles F; Dhanak, Dashyant; Prinjha, Rab K; Auger, Kurt R; Tummino, Peter J

Natural mutagenesis of human genomes by endogenous retrotransposons

内源性逆转录转座子对人类基因组的自然诱变

Iskow, Rebecca C; McCabe, Michael T; Mills, Ryan E; Torene, Spencer; Pittard, W Stephen; Neuwald, Andrew F; Van Meir, Erwin G; Vertino, Paula M; Devine, Scott E

Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells

宫颈癌细胞中STK11/LKB1基因座的纯合缺失及新型融合转录本的产生

McCabe, Michael T; Powell, Doris R; Zhou, Wei; Vertino, Paula M