日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

通过筛选 nsp13 解旋酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Jingkun Zeng #, Florian Weissmann #, Agustina P Bertolin #, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F X Diffley

Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA.

SNARE样蛋白IncA介导的衣原体包涵体同型融合的结构基础

Cingolani Gino, McCauley Michael, Lobley Anna, Bryer Alexander J, Wesolowski Jordan, Greco Deanna L, Lokareddy Ravi K, Ronzone Erik, Perilla Juan R, Paumet Fabienne

Relation between therapy-induced changes in natriuretic peptide levels and long-term therapeutic effects on mortality in patients with heart failure and reduced ejection fraction

治疗引起的利钠肽水平变化与射血分数降低的心力衰竭患者长期死亡率治疗效果之间的关系

Wessler, Benjamin S; McCauley, Michael; Morine, Kevin; Konstam, Marvin A; Udelson, James E

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

荧光传感器用于检测 PARP-1 结构动力学和变构调节对 DNA 损伤的反应

Steffen, Jamin D; McCauley, Michael M; Pascal, John M

KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models

KPT-330 是一种强效选择性的 Exportin-1 (XPO-1) 抑制剂,在前列腺癌模型中表现出调节细胞周期蛋白 D1 和 Survivin [更正] 表达的抗肿瘤作用

Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Claudio Festuccia

XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)

XPO1/CRM1 选择性核输出抑制剂 (SINE) 可减少前列腺癌 (PCa) 临床前模型中的肿瘤扩散并提高总体生存率

Giovanni Luca Gravina, Monica Tortoreto, Andrea Mancini, Alessandro Addis, Ernesto Di Cesare, Andrea Lenzi, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Nadia Zaffaroni, Claudio Festuccia

Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study

新型口服生物可利用核输出选择性抑制剂 (SINE) KPT-335 在自发性犬癌中的临床前评估:I 期研究结果

Cheryl A London, Luis Feo Bernabe, Sandra Barnard, William C Kisseberth, Antonella Borgatti, Mike Henson, Heather Wilson, Kiersten Jensen, Daisuke Ito, Jaime F Modiano, Misty D Bear, Michael L Pennell, Jean-Richard Saint-Martin, Dilara McCauley, Michael Kauffman, Sharon Shacham

The H1N1 pandemic: media frames, stigmatization and coping

H1N1流感大流行:媒体框架、污名化与应对

McCauley, Michael; Minsky, Sara; Viswanath, Kasisomayajula