日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

利用啮齿动物笼内环境监测进行临床前安全性药理学评估:一项多公司验证研究的结果,该研究评估了三种化合物的非临床和临床数据。

Sillito, R R; Sutherland, J; Milne, A; Giuliano, C; Sigfridsson, C; Rolf, M; Cherian, A K; McClafferty, M; Rossman, E I; Teuns, G; Armstrong, J D; Holmes, A M

Distinct domains of LINGO1 control surface expression and biophysical properties of large conductance Ca(2+)- and voltage-activated potassium (BK) channels

LINGO1的不同结构域控制着大电导Ca(2+)通道和电压激活钾(BK)通道的表面表达和生物物理特性。

Al Kawadri, Yaly; McClafferty, Heather; Dudem, Srikanth; Rabab, Kaneez E; Thornbury, Keith D; Sergeant, Gerard P; Hollywood, Mark A; Shipston, Michael J

Safe system approach to preventing cyclist fatalities: safety by design for urban and rural environments

采取安全系统方法预防骑行者死亡:城市和乡村环境的安全设计

Charyk Stewart, Tanya; Pellar, Allison; Halari, Moheem; McClafferty, Kevin; Verville, Pascal; Pickup, Michael; Fraser, Douglas; Gilliland, Jason; Shkrum, Michael

A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

一种新型人类多能干细胞基因激活系统发现IGFBP2是体外造血祖细胞生成过程中的介质。

Paolo Petazzi ,Telma Ventura ,Francesca Paola Luongo ,Heather McClafferty ,Alisha May ,Helen Alice Taylor ,Michael J Shipston ,Nicola Romanò ,Lesley M Forrester ,Pablo Menendez ,Antonella Fidanza

Long-term, Dynamic Remodelling of the Corticotroph Transcriptome and Excitability After a Period of Chronic Stress

长期动态重塑促肾上腺皮质激素细胞转录组和兴奋性在慢性应激后的变化

Duncan, Peter J; Romanò, Nicola; Nair, Sooraj V; McClafferty, Heather; Le Tissier, Paul; Shipston, Michael J

Comparing the effects of infant maternal and sibling separation on adolescent behavior in rats (Rattus norvegicus)

比较幼鼠与母亲和兄弟姐妹分离对大鼠(Rattus norvegicus)青少年行为的影响

McClafferty, Shane R; Paniagua-Ugarte, Claudia; Hannabass, Zoe M; Jackson, Pamela A; Hayes, Dayna M

Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels

氧化调节 LINGO2 诱导的大电导 Ca2+ 激活钾通道失活

Srikanth Dudem, Pei Xin Boon, Nicholas Mullins, Heather McClafferty, Michael J Shipston, Richard D A Wilkinson, Ian Lobb, Gerard P Sergeant, Keith D Thornbury, Irina G Tikhonova, Mark A Hollywood

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

平滑肌中 AMPK 缺乏导致新生儿持续性肺动脉高压和过早死亡

Javier Moral-Sanz, Sophronia A Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge Del-Pozo, A Mark Evans

Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the hypothalamus-pituitary-adrenal axis

从Pomc-eGFP小鼠中分离促肾上腺皮质激素细胞,揭示了持续的转录失调,这是糖皮质激素诱导的下丘脑-垂体-肾上腺轴抑制小鼠模型的特征。

Duncan, Peter J; McClafferty, Heather; Nolan, Oscar; Ding, Qinghui; Homer, Natalie Z M; Le Tissier, Paul; Walker, Brian R; Shipston, Michael J; Romanò, Nicola; Chambers, Thomas J G

Gastrointestinal Manifestations of COVID-19: A Review of What We Know

新冠肺炎的胃肠道表现:我们已知信息的综述

Groff, Andrew; Kavanaugh, Madison; Ramgobin, Devyani; McClafferty, Brendan; Aggarwal, Chander Shekher; Golamari, Reshma; Jain, Rohit