文献库，生知库 | 链接生命科学的每一步

日期影响因子

A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes

具有不同有氧能力的多基因大鼠模型揭示了肝脑相互作用对阿尔茨海默病样表型的影响

期刊:Journal of Physiology-London

影响因子:4.4

doi:10.1113/JP286750

Lysaker, Colton R; Kugler, Benjamin A; Csikos, Vivien; Birky, Cole J; Gilmore, Caleb A; Wenger, Madi; Franczak, Edziu; Davis, Xin; Hauger, Brittany M; Allen, Julie A; Troutwine, Benjamin R; Gonzalez-Duran, Laura; McCoin, Colin S; Chauhan, Munish; Harris, Janna L; Frazier, Alexandria L; Winter, Michelle K; Koch, Lauren G; Britton, Steven L; Thyfault, John P; Wilkins, Heather M

阿尔茨海默症

发表日期：2026

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Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

异生物质代谢紊乱和线粒体功能障碍会加剧人抗原R缺陷雄性小鼠对乙酰氨基酚诱导的肝毒性。

doi:10.64898/2026.01.28.702297

Eppler, Natalie; Jones, Elizabeth; Ahamed, Forkan; Raja, Naren; Akakpo, Jephte Y; Lebofsky, Margitta; He, Lily; Vats, Ira; Ghosh, Priyanka; Yu, Yifan; Thomas, Kaitlyn; McCoin, Colin; Thyfault, John; Wu, Xiaoqing; Xu, Liang; Cui, Wei; Wang, Rong; Jaeschke, Hartmut; Zhang, Yuxia

发表日期：2026

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A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms.

地下动物隐花色素-1中反复出现的突变会改变其行为和分子昼夜节律

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2025.112874

Swaminathan Amruta, Kenzior Alexander, Price Andrew, Li Hua, McCoin Colin, Hintermann AurÃ©lie, Weaver Kyle, Morris NatiCia, Keene Alex C, Rohner Nicolas

发表日期：2025

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APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model.

在临床前模型中，APOE4 对能量消耗和骨骼肌线粒体通路产生部分饮食依赖性影响

期刊:Function

影响因子:3.8

doi:10.1093/function/zqaf017

Johnson Chelsea N, Lysaker Colton R, Gast Elaine C, McCoin Colin S, Kemna Riley E, Fuller Kelly N Z, Kugler Benjamin A, Franczak Edziu, Csikos Vivien, Allen Julie, John Casey S, Wolf MaryJane A, Morris Matthew E, Thyfault John P, Wilkins Heather M, Geiger Paige C, Morris Jill K

发表日期：2025

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Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models.

多奈哌齐治疗，无论是单独使用还是与运动结合使用，都能增强健康和衰老疾病小鼠模型的骨骼肌功能。

期刊:Journal of Applied Physiology

影响因子:3.3

doi:10.1152/japplphysiol.00895.2024

Ernst Nicholas J, Franczak Edziu, Allen Julie, Minchew Everett C, Readyoff Andrew T, Farlow Miles C, Spangenburg Espen E, Miller Benjamin F, Morris Jill K, Shankar Kartik, Sardiu Mihaela E, Zhu Hao, Stanford John A, Thyfault John P, McCoin Colin S

发表日期：2025

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Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux.

卵巢功能丧失会阻止运动诱导的肝脏线粒体自噬通量的激活

期刊:American Journal of Physiology-Endocrinology and Metabolism

影响因子:3.1

doi:10.1152/ajpendo.00107.2025

Franczak Edziu, Kugler Benjamin A, Salathe Sebastian F, Allen Julie A, Sardiu Mihaela E, McCoin Colin S, Hevener Andrea L, Morris E Matthew, Thyfault John P

发表日期：2025

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Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle

肝脏生酮功能不足会减弱运动引起的能量消耗，并改变骨骼肌中的线粒体蛋白。

doi:10.1101/2025.09.16.676620

Davis, Xin C; McCoin, Colin S; Salathe, Sebastian F; Franczak, Edziu; Allen, Julie A; Queathem, Eric D; Fulghum, Kyle L; Puchalska, Patrycja; Crawford, Peter A; Thyfault, John P; Morris, E Matthew

发表日期：2025

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Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis.

蛋白质组学和代谢组学分析揭示了 APOE4 依赖性的全脑、神经元和星形胶质细胞线粒体功能和糖酵解的变化

doi:10.1101/2025.06.15.659811

Lysaker Colton R, Johnson Chelsea N, Csikos Vivien, Franczak Edziu, Benson Maggie, Gilmore Caleb A, Birky Cole J, Davis Xin, McCoin Colin S, Smith Keith P, Puchalska Patrycja, Crawford Peter, Slawson Chad, Thyfault John P, Geiger Paige C, Morris Jill K, Wilkins Heather M

发表日期：2025

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Sexually dimorphic hepatic mitochondrial adaptations to exercise: a mini-review

肝脏线粒体对运动的性别二态性适应：简要综述

期刊:Journal of Applied Physiology

影响因子:3.3

doi:10.1152/japplphysiol.00711.2022

Kugler, Benjamin A; Thyfault, John P; McCoin, Colin S

发表日期：2023

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Divergence in aerobic capacity influences hepatic and systemic metabolic adaptations to bile acid sequestrant and short-term high-fat/sucrose feeding in rats

大鼠有氧能力差异会影响肝脏和全身代谢对胆汁酸螯合剂和短期高脂/蔗糖喂养的适应性

期刊:American Journal of Physiology-Regulatory Integrative and Comparative Physiology

影响因子:2.3

doi:10.1152/ajpregu.00133.2023

Kugler, Benjamin A; Cao, Xin; Wenger, Madi; Franczak, Edziu; McCoin, Colin S; Von Schulze, Alex; Morris, E Matthew; Thyfault, John P

发表日期：2023

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